农业生物技术学报2026，Vol.34Issue(3)：510-520,11.DOI:10.3969/j.issn.1674-7968.2026.03.006
MSTN基因调控动物肠道微生物组的研究进展及靶向益生菌应用前景
Research Advances in MSTN Gene Regulation of Animal Gut Microbiome and Application Prospects for Targeted Probiotics
摘要
Abstract
Myostatin(MSTN)is a key factor widely present in higher animals,primarily involved in the regulation of muscle development and lipid metabolism.Loss-of-function mutations or downregulated expression of MSTN can consistently induce a significant"double-muscling"phenotype in various animal models.Recent studies have further revealed that in animals with MSTN gene mutations,the structure and function of their gut microbiota undergo specific remodeling,which serves as a central mediator to significantly regulate the host's energy metabolism and muscle-fat balance.As the"second genome"of the host,gut microbes have been demonstrated to profoundly influence host metabolism and physiological functions.This review focusing on the important metabolic regulator MSTN,systematically reviews research progress on the changes in gut microbiota of MSTN-mutated animals,the correlation between MSTN activity and gut microbiota in non-genetically edited animal models,the mechanisms by which MSTN inhibition mediates gut microbiota remodeling to influence host metabolism,and the potential and challenges of exploring probiotics targeting the MSTN pathway.Through this perspective,the review aimed to elucidate the interaction between host genetic traits and gut microbial communities,providing a comprehensive scientific reference and clear research directions for the efficient development and utilization of genetically edited animal resources with significant economic value(particularly in meat animal breeding and production enhancement),especially their unique and regulable microbiome resources.关键词
肌肉生长抑制素(MSTN)/基因编辑动物/肠道微生物/代谢调控/益生菌挖掘Key words
Myostatin(MSTN)/Gene editing animals/Gut microbiota/Metabolic regulation/Probiotic mining分类
农业科技引用本文复制引用
高丽,王利利,温彤..MSTN基因调控动物肠道微生物组的研究进展及靶向益生菌应用前景[J].农业生物技术学报,2026,34(3):510-520,11.基金项目
内蒙古自治区自然科学基金优秀青年基金(2025YQ024) （2025YQ024）
内蒙古自治区自然科学基金面上项目(2025MS03098) （2025MS03098）
