世界中医药2025，Vol.20Issue(20)：3778-3784,7.DOI:10.3969/j.issn.1673-7202.2025.20.025
基于脑-肠轴理论指导下葛根芩连汤干预代谢性脑血管病作用机制
Mechanisms of Gegen Qinlian Decoction in Intervening Metabolic Cerebrovascular Disease Based on Brain-gut Axis
摘要
Abstract
China has the highest lifetime risk of stroke globally,with metabolic abnormalities as the primary risk factor.Metabolic cerebrovascular disease is a recently proposed concept,referring to cerebrovascular damage caused by the interaction of multiple metabolic risk factors.Targeting common regulatory pathways of these metabolic risk factors represents a key research direction for the prevention and treatment of metabolic cerebrovascular diseases.Gegen Qinlian Decoction(GQD),based on the brain-gut axis theory,exerts multi-component synergistic effects by integrating gut microbiota regulation,modulating glucose and lipid metabolism,improving insulin resistance,providing anti-atherosclerotic effects,and offering neurovascular protection.These mechanisms collec-tively regulate metabolic risk factors and provide novel scientific evidence supporting integrated traditional Chinese and Western medicine strategies for metabolic cerebrovascular disease.Future studies should continue to explore the novel applications of classi-cal formulas,using approaches such as network pharmacology,transcriptomics,and metabolomics to further elucidate the main path-ways and mechanisms through which the active components of GQD intervene in metabolic cerebrovascular disease via the brain-gut axis,thereby providing a scientific basis for the prevention and treatment of stroke and its chronic comorbidities.关键词
代谢性脑血管病/代谢危险因素/脑-肠轴/葛根芩连汤/短链脂肪酸Key words
Metabolic cerebrovascular disease/Metabolic risk factors/Brain-gut axis/Gegen Qinlian Decoction/Short-chain fatty acids分类
医药卫生引用本文复制引用
郝媌,王越,曹菁,乔利军,孙向荣..基于脑-肠轴理论指导下葛根芩连汤干预代谢性脑血管病作用机制[J].世界中医药,2025,20(20):3778-3784,7.基金项目
国家自然科学基金项目(31971060)——基于脑肠轴研究钙敏感受体对摄食及胃肠运动调控的外周及中枢机制 （31971060）
山东省中医药科技项目(M-2023155)——基于"脑-肠"轴理论探讨葛根芩连汤加减治疗急性缺血性卒中合并代谢综合征患者的临床研究 （M-2023155）
青岛市医疗卫生优秀青年医学人才(青卫科教字2024-3) （青卫科教字2024-3）
