世界中医药2025，Vol.20Issue(19)：3554-3563,10.DOI:10.3969/j.issn.1673-7202.2025.19.023
中医药调控氧化应激机制抗脑缺血再灌注损伤的研究进展
Research Progress on the Mechanism of Traditional Chinese Medicine in Regulating Oxidative Stress Against Cerebral Ischemia-reperfusion Injury
摘要
Abstract
Ischemic stroke(IS)is a disease characterized by cerebral ischemia and hypoxia,which leads to pathological damages such as neuronal necrosis and functional disorders.It exhibits a high incidence rate and a high disability rate.Cerebral ischemia/reperfusion injury(CIRI)serves as the primary secondary injury,which can lead to permanent disability or even death in severe ca-ses.The main pathological mechanisms of CIRI encompass oxidative stress(OS),calcium overload,inflammatory responses,autoph-agy and apoptosis,etc.Among these mechanisms,oxidative stress is regarded as the fundamental basis of CIRI.Therefore,it is of great significance to target oxidative stress for treating CIRI.Oxidative stress is triggered when the equilibrium between the oxidative and antioxidant systems in the body or tissues is disrupted.Excessive production of reactive oxygen species causes protein denatur-ation,DNA damage,lipid peroxidation,and other detrimental effects,mediating cellular and tissue damage through multiple path-ways.With the development of traditional Chinese medicine(TCM),the research on TCM in treating CIRI has made substantial progress.A multitude of studies have also demonstrated that numerous TCM compounds and components can effectively treat CIRI by exerting antioxidant stress effects.关键词
氧化应激/脑缺血再灌注损伤/中医药/信号通路/中药单体成分/中药复方/作用机制/研究进展Key words
Oxidative stress/Cerebral ischemia-reperfusion injury(CIRI)/Traditional Chinese medicine/Signaling pathways/TCM monomer components/TCM compound/Mechanism of action/Research progress分类
医药卫生引用本文复制引用
邹倩倩,周盼盼,李毅乐,王蕾,张硕,崔应麟..中医药调控氧化应激机制抗脑缺血再灌注损伤的研究进展[J].世界中医药,2025,20(19):3554-3563,10.基金项目
国家中医药管理局2022年第二届全国名中医传承工作室建设项目(国中医药办人教函[2022]245号) （国中医药办人教函[2022]245号）
