世界睡眠医学杂志2025，Vol.12Issue(10)：2249-2252,4.DOI:10.3969/j.issn.2095-7130.2025.10.030
灵芝和肝汤联合疏肝健脾针法治疗失眠的临床研究
Clinical Study on the Treatment of Insomnia with Liver-calming Lingzhi Decoction Combined with Liver-soothing and Spleen-invigorating Acupuncture
陶鸿燕 1李洁莲2
作者信息
- 1. 广东药科大学虎门中医院,东莞,523900
- 2. 东莞市松山湖高新技术产业开发区社区卫生服务中心,东莞,523900
- 折叠
摘要
Abstract
Objective:To observe the clinical efficacy of Liver-Calming Lingzhi Decoction combined with liver-soothing and spleen-invigorating acupuncture in the treatment of insomnia.Methods:A total of 238 patients with insomnia who were treated at Humen Hospital of Traditional Chinese Medicine From January 2023 to January 2025,Guangdong Pharmaceutical University(treatment period not specified),were enrolled as study participants.According to the random number table method,they were di-vided into a control group and an observation group,with 119 cases in each group.The control group received oral estazolam,while the observation group was treated with Liver-Calming Lingzhi Decoction combined with liver-soothing and spleen-invigorating acu-puncture.Both groups were treated for 14 days.The Pittsburgh Sleep Quality Index(PSQI)was used to evaluate sleep quality be-fore and after treatment.Enzyme-linked immunosorbent assay(ELISA)was used to measure serum levels of 5-hydroxytryptamine(5-HT)and dopamine(DA).Treatment efficacy was compared between the two groups.Results:After intervention,the total effec-tive rate in the observation group was significantly higher than that in the control group.PSQI scores in the observation group were significantly lower than those in the control group,while 5-HT levels were higher and DA levels were lower than those in the control group.The differences between the two groups were statistically significant(P＜0.05).Conclusion:The combination of Liver-Cal-ming Lingzhi Decoction and liver-soothing and spleen-invigorating acupuncture is effective in improving sleep quality and modulating neurotransmitter levels(5-HT and DA)in patients with insomnia.This therapy is safe,effective,and worthy of clinical promotion.关键词
失眠/灵芝和肝汤/疏肝健脾针法/睡眠质量/5-羟色胺/多巴胺Key words
Insomnia/Lingzhi(Ganoderma)/Liver-Calming Lingzhi Decoction/Liver-soothing and spleen-invigorating acupunc-ture/Sleep quality/5-hydroxytryptamine/Dopamine分类
医药卫生引用本文复制引用
陶鸿燕,李洁莲..灵芝和肝汤联合疏肝健脾针法治疗失眠的临床研究[J].世界睡眠医学杂志,2025,12(10):2249-2252,4.
