世界中医药2025，Vol.20Issue(19)：3564-3573,3578,11.DOI:10.3969/j.issn.1673-7202.2025.19.024
线粒体代谢对心力衰竭的影响及中医药干预研究进展
Effects of Mitochondrial Metabolism on Heart Failure and Research Progress of Traditional Chinese Medicine Intervention
摘要
Abstract
Heart failure is a severe clinical syndrome that typically arises from various heart diseases and constitutes the final stage of most cardiovascular diseases.The onset of heart failure is closely related to abnormal energy metabolism in cardiomyocytes,and mitochondria,as an important organelle,serve as the primary energy source of cardiomyocytes.Consequently,the regulation of mito-chondrial metabolism is of great significance for the prevention and treatment of heart failure.Currently,it is widely recognized that the pathological state of heart failure resembles the myocardial alterations caused by mitochondrial metabolic disorders.Multiple as-pects of mitochondrial activity are implicated in the occurrence and progression of HF,including mitochondrial dynamics,calcium homeostasis,oxidative stress and inflammatory responses,autophagy-mediated apoptosis,and mitochondrial-associated endoplasmic reticulum membranes(MAMs).Traditional Chinese medicine(TCM)offers diverse approaches to modulating mitochondrial metabo-lism through single herbs,isolated active components,or effective ingredients,as well as through TCM compound preparations and patent medicines.These interventions operate via multi-component,multi-target,and multi-pathway mechanisms,ultimately impro-ving cardiac function and aiding in the prevention and treatment of heart failure.关键词
心力衰竭/线粒体代谢/线粒体动力学/线粒体钙稳态/线粒体氧化应激/炎症反应/线粒体自噬/线粒体-内质网结构偶联/心功能Key words
Heart failure/Mitochondrial metabolism/Mitochondrial dynamics/Mitochondrial calcium homeostasis/Mitochondrial oxidative stress/Inflammatory response/Mitophagy/Mitochondrial-associated endoplasmic reticulum membranes(MAMs)/Cardi-ac function分类
医药卫生引用本文复制引用
宋淼豫,朱翠玲,李一卓,李晓辉,姜雷,岳朝冲..线粒体代谢对心力衰竭的影响及中医药干预研究进展[J].世界中医药,2025,20(19):3564-3573,3578,11.基金项目
国家自然科学基金青年科学基金项目(82405290) （82405290）
国家中医药管理局-张仲景传承与创新专项(GZY-KJS-2022-044-2) （GZY-KJS-2022-044-2）
河南省中医药科学研究专项(2023ZY2027) （2023ZY2027）
