生物加工过程2026，Vol.24Issue(1)：16-28,13.DOI:10.3969/j.issn.1672-3678.2026.01.002
人乳寡糖微生物合成的研究进展
Recent advances in the microbial synthesis of human milk oligosaccharides
摘要
Abstract
Human milk oligosaccharides(HMOs)are composed of lactose and four other monosaccharide units arranged in various combinations and are one of the key components in human milk that play an important role in the growth and development of infants.Advances in molecular biology and metabolic engineering have led to substantial progress in the microbial synthesis of HMOs.Nevertheless,the yield of HMOs remains insufficient to meet the demands of research and large-scale applications.This paper briefly introduces the structural composition of HMOs and the current status of microbial synthesis research.It focuses on the design of efficient cell factories based on the structural formulas of HMOs and various metabolic engineering strategies to enhance HMOs production,and also presents an outlook on the future prospects of HMOs biosynthesis.关键词
人乳寡糖/细胞工厂/代谢工程策略Key words
HMOs/cell factory/metabolic engineering strategies分类
生物科学引用本文复制引用
冷静,应汉杰,李梦婷,杨思琪,蒋宇,孙兵兵,柳东,陈勇,牛欢青,杨晟..人乳寡糖微生物合成的研究进展[J].生物加工过程,2026,24(1):16-28,13.基金项目
长江学者与高校创新研究团队项目(IRT_14R28) （IRT_14R28）
国家重点研发计划(2021YFC2101204) （2021YFC2101204）
国家自然科学基金面上项目(22178172) （22178172）
江苏省重点研发计划(BE2019001) （BE2019001）
江苏省前沿引领技术基础研究专项(BK20202002) （BK20202002）
江苏省先进生物制造协同创新中心自主研发课题(XTD2212) （XTD2212）
江苏省高校优先学术项目(PAPD) （PAPD）
