生物加工过程2026，Vol.24Issue(1)：74-83,99,11.DOI:10.3969/j.issn.1672-3678.2026.01.008
基于上转换纳米粒子的光触发联合疗法在肿瘤治疗中的应用
Application of photo-triggered combination therapy based on upconversion nanoparticle in cancer treatment
摘要
Abstract
Photodynamic therapy(PDT)has emerged as a promising treatment for tumors and has gained widespread attention in recent years.However,ultraviolet-visible(UV/VIS)light traditionally used to activate photosensitizers has limited tissue penetration,which significantly limits the therapeutic efficacy of PDT.Upconversion nanoparticles(UCNPs)have stronger tissue penetration capabilities and can convert near-infrared(NIR)light into UV/VIS light.When used as carriers for photosensitizers,UCNPs enable NIR-triggered activation of photosensitizers.Consequently,the development of a PDT system based on UCNPs presents a novel approach for enhancing PDT effectiveness.Furthermore,this system can also load other drugs via UCNPs,facilitating multimodal combination therapy.This review summarizes the research progress of UCNP-based PDT systems in combination therapy,explores the mechanisms of photo-triggered drug release,and evaluates the biosafety of these combination therapy systems,providing valuable insights for their clinical application.关键词
上转换纳米粒子/光触发/联合治疗/光动力/生物安全性Key words
UCNPs/photo-triggered/combination therapy/photodynamic/biosafety分类
化学化工引用本文复制引用
王森,聂丽蓉,郭栋,郑佳宇,卢明夏..基于上转换纳米粒子的光触发联合疗法在肿瘤治疗中的应用[J].生物加工过程,2026,24(1):74-83,99,11.基金项目
上海市青年科技英才扬帆计划(21FY1431300) （21FY1431300）
