实用肝脏病杂志2026，Vol.29Issue(1)：33-36,4.DOI:10.3969/j.issn.1672-5069.2026.01.009
富马酸丙酚替诺福韦与替诺福韦二吡呋酯阻断HBV感染孕妇病毒母婴传播效果比较
Comparative study on prevention of mother-to-child HBV transmission by tenofovir alafenamide fumarate and tenofovir disoproxil fumarate in pregnant HBV carriers
摘要
Abstract
Objective This study aimed to compare prevention of mother-to-child hepatitis B virus(HBV)transmission by tenofovir alafenamide fumarate(TAF)and tenofovir disoproxil fumarate(TDF)in pregnant HBV carriers.Methods 62 pregnant chronic HBV carriers were encountered in our hospital between May 2022 and May 2024,and were randomly assigned to receive TDF in 31 cases or TAF anti-viral therapy in another 31 cases since gestation 26 to 28 weeks until childbirth.All newborns were inoculated with hepatitis B immune globulin and hepatitis B vaccine.Serum creatinine(sCr)level and 24-hour urinary protein quantification were measured by using a fully automated biochemical analyzer,and the estimated glomerular filtration rate(eGFR)was calculated by using the CKD-EPI formula.Serum HBeAg levels were detected by chemiluminescence,and serum HBV DNA loads were measured by fluorescent quantitative PCR system.Results By end of one year follow-up,the successful blocking of mother-to-child HBV transmission in TAT-treated women was 100.0％,not significantly different as compared to 96.8％(P＞0.05)in TDF-treated women;at laboring,serum HBV DNA turned to negative in the two groups,and serum HBeAg levels dint changed greatly(P＞0.05);sCr,eGFR and urine protein level in TAF-treated women were(86.1±5.9)μmol/L,(96.6±8.2)mL/(min.1.73m2 and(97.5±22.1)mg/24 h,all not significantly different compared to[(88.1±5.7)μmol/L,(94.4±7.9)mL/(min.1.73m2 and(99.7±28.2)mg/24 h,P＞0.05)in TDF-treated women;incidences of adverse events,such as premature birth,premature rupture of membranes and gestational hypertension in the two groups were not significantly different(P＞0.05).Conclusion At present,we recommend both TDF or TAF for prevention of mother-to-child HBV transmission,which warrants further clinical observation.关键词
乙型肝炎病毒携带者/富马酸丙酚替诺福韦/替诺福韦二吡呋酯/母婴传播/孕妇Key words
Hepatitis B carriers/Tenofovir alafenamide fumarate/Tenofovir disoproxil fumarate/Mother-to-child transmission/Prevention引用本文复制引用
王美,白洁,赵春..富马酸丙酚替诺福韦与替诺福韦二吡呋酯阻断HBV感染孕妇病毒母婴传播效果比较[J].实用肝脏病杂志,2026,29(1):33-36,4.基金项目
四川省科技厅科研计划项目(编号:2022YFS0094) （编号:2022YFS0094）
