实用肿瘤杂志2026，Vol.41Issue(1)：66-71,6.DOI:10.13267/j.cnki.syzlzz.2026.010
原发性肝细胞癌患者XRCC1基因rs25487多态性与血清甲胎蛋白水平的相关性分析
Correlation between rs25487 polymorphism of XRCC1 gene and serum alpha-fetoprotein level in patients with primary hepatocellular carcinoma
摘要
Abstract
Objective To investigate the association between the single nucleotide polymorphism of X-ray repair cross com-plementing group 1(XRCC1)gene and serum alpha-fetoprotein(AFP)level in patients with hepatocellular carcinoma(HCC).Methods A total of 380 patients with primary HCC who underwent surgical resection and 361 healthy individuals who had phys-ical examination at Affiliated Yantai Yuhuangding Hospital,Qingdao University Medical College,between January 2014 and Sep-tember 2024,were recruited as the HCC group and control group,respectively.The genotyping of the XRCC1 rs25487 locus was performed using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Serum AFP level was quan-tified using a chemiluminescence immunoassay analyzer.The relationship between rs25487 polymorphism and serum AFP lev-el was assessed using linear regression analysis.Results In the codominant model of the HCC group,serum AFP levels were(56.88±72.85),(110.91±315.90),and(342.12±1 698.08)ng/mL for the GG(n=167),GC(n=101),and CC(n=112)genotypes(P＜0.01).Compared to those of the GG genotype,the carriers of the GC and CC genotypes exhibited a 95.0%increase(P=0.044)and a 501.4%increase(P＜0.01)in the mean serum AFP level,respectively.In the dominant model,the carriers of the GC/CC geno-type showed a 308.7%increase in the mean serum AFP level compared to that with the GG genotype[(232.49±1 253.08)ng/mL vs(56.88±72.85)ng/mL,P＜0.01].In the recessive model,the carriers of the CC genotype exhibited a 342.9%increase in the mean se-rum AFP level compared to that of the GC/GG genotype[(342.12±1 698.08)ng/mL vs(77.24±203.38)ng/mL,P＜0.01].Multiple lin-ear regression analysis confirmed that rs25487 genotype was independently associated with serum AFP level in HCC patients(P＜0.01).Conclusions The rs25487 polymorphism of XRCC1 gene is independently associated with serum AFP level in HCC patients.The carriers of the C allele at the XRCC1 rs25487 locus have significantly elevated serum AFP level.关键词
肝细胞癌/单核苷酸多态性/甲胎蛋白/X线修复交叉互补蛋白1/rs25487Key words
hepatocellular carcinoma/single nucleotide polymorphism/alpha-fetoprotein/X-ray repair cross complementing group 1/rs25487引用本文复制引用
殷浩铭,潘正龙,朱俊涛,刘小方..原发性肝细胞癌患者XRCC1基因rs25487多态性与血清甲胎蛋白水平的相关性分析[J].实用肿瘤杂志,2026,41(1):66-71,6.基金项目
湖北陈孝平科技发展基金会青年科学专项基金(CXPJJH123001-2319) （CXPJJH123001-2319）
