天津中医药2026，Vol.43Issue(2)：193-204,12.DOI:10.11656/j.issn.1672-1519.2026.02.09
补肾活血类方剂治疗膝关节骨性关节炎的Meta分析及中药处方数据挖掘
Meta-analysis of kidney-tonifying and blood-activating formula in the treatment of knee osteoarthritis and data mining of herbal prescriptions
摘要
Abstract
[Objective]To systematically evaluate the efficacy and safety of oral kidney-tonifying and blood-activating Chinese herbal formulas in treating knee osteoarthritis(KOA),and to explore the prescribing patterns.[Methods]Randomized controlled trials(RCTs)published between January 2015 and April 2025 were retrieved from eight databases including CNKI,Wanfang Database,and PubMed.Studies meeting the inclusion criteria were screened,and data were extracted for Meta-analysis.Statistical analysis was performed using RevMan 5.4 and Stata 17.0 software.Outcomes such as total effective rate,WOMAC score,VAS score,Lequesne index,and adverse events were pooled.Additionally,frequency analysis,property-flavor-meridian distribution,association rule analysis,and cluster analysis were conducted on the included herbal prescriptions.[Results]A total of 14 RCTs involving 1 198 patients were included.The meta-analysis showed that kidney-tonifying and blood-activating herbal formulas were superior to conventional Western medicine in terms of total effective rate[OR=2.58,95%CI(1.87,3.57)],WOMAC score[OR=-2.64,95%CI(-3.96,-0.96)],VAS score[OR=-0.63,95%CI(-0.85,-0.42)],and Lequesne index[OR=-1.09,95%CI(-1.37,-0.80),P<0.05],with no significant difference in adverse events[OR=0.60,95%CI(0.25,1.34),P=0.25].Data mining revealed that high-frequency herbs included Achyranthes bidentata,Rehmannia glutinosa and Angelica sinensis.Herbal properties were primarily warm and neutral,and meridians were mainly linked to the liver,kidney,and spleen.The core herb pair was Achyranthes bidentata and Spatholobus suberectus(confidence 100%).[Conclusion]When used alone,kidney-tonifying and blood-activating Chinese herbal formulas demonstrate a superior trend in efficacy compared to conventional Western medicine alone in improving clinical symptoms,joint function,and pain in patients with KOA,with comparable safety.The prescribing pattern aligns with the traditional Chinese medicine theory of"tonifying the kidney and activating blood",with the Achyranthes-Spatholobus pair being central.Further in-depth research is warranted.关键词
补肾活血/膝关节骨性关节炎/Meta分析/数据挖掘/中药Key words
kidney-tonifying and blood-activating/knee osteoarthritis/Meta-analysis/data mining/Chinese herbal medicine分类
医药卫生引用本文复制引用
杜超,杨家麟,陈睿思,钟吉崴,曹东东,郭天赐,吴维勇,刘爱峰..补肾活血类方剂治疗膝关节骨性关节炎的Meta分析及中药处方数据挖掘[J].天津中医药,2026,43(2):193-204,12.基金项目
国家自然科学基金面上项目(82474538) （82474538）
天津市卫生健康委员会津门医学英才项目(TJSJMYXYC-D2-028). （TJSJMYXYC-D2-028）
