实用妇产科杂志2026，Vol.42Issue(1)：82-86,5.
妊娠早期血红蛋白和血清铁蛋白预测子痫前期的价值分析
Analysis on the Value of Hemoglobin and Serum Ferritin in Predicting Pre-eclampsia during Early Pregnancy
摘要
Abstract
Objective:To explore the predictive value of hemoglobin and serum ferritin levels in early pregnan-cy for preeclampsia,so as to provide a basis for early clinical screening.Methods:A retrospective case-control study was conducted.A total of 321 pregnant women who received prenatal examination and delivered in Yin-chuan Maternal and Child Health Hospital from May 1,2022 to February 28,2024 were selected.They were divided into the observation group(164 cases)and the control group(157 cases)according to whether preeclampsia was diagnosed.The observation group was further divided into the non-severe preeclampsia subgroup(80 cases)and the severe preeclampsia subgroup(84 cases)according to disease classification.The detection data of hemoglo-bin,serum ferritin and serum iron in early pregnancy(10-13+6 weeks)were collected and compared.Univariate Logistic regression analysis was used to screen the risk factors related to preeclampsia,and the receiver operat-ing characteristic(ROC)curve and the area under the curve(AUC)were used to evaluate the predictive efficacy of each index and combined detection.Results:The levels of hemoglobin(129.85±12.92 g/L vs.125.62±10.43 g/L)and serum ferritin(44.27 μg/L vs.32.30 μg/L)in the observation group were significantly higher than those in the control group(P<0.05).However,there was no statistically significant difference in hemoglobin and serum ferritin levels between the severe preeclampsia subgroup and the non-severe preeclampsia subgroup(P>0.05).Univariate Logistic regression analysis showed that hemoglobin(OR 1.037,95％CI 1.014-1.061)and ser-um ferritin(OR 1.013,95％CI 1.005-1.022)were influencing factors for preeclampsia(P<0.05).ROC curve a-nalysis showed that the cut-off value of serum ferritin for predicting preeclampsia was 30.25 μg/L(sensitivity 78.7％,specificity 47.8％,AUC 0.624),the cut-off value of hemoglobin was 127.63 g/L(sensitivity 62.2％,speci-ficity56.7％,AUC0.624),the specificity of combined detection was increased to70.7％(AUC0.642).Conclu-sions:The increased levels of hemoglobin and serum ferritin in early pregnancy are significantly associated with the occurrence of preeclampsia,which can be used as independent predictive indicators.Combined detection can improve the predictive specificity and has potential clinical application value.关键词
子痫前期/血红蛋白/血清铁蛋白/预测/妊娠早期Key words
Preeclampsia/Hemoglobin/Serum ferritin/Predicting/Early Pregnancy分类
医药卫生引用本文复制引用
雍敏婕,别荔,杨丽娜..妊娠早期血红蛋白和血清铁蛋白预测子痫前期的价值分析[J].实用妇产科杂志,2026,42(1):82-86,5.基金项目
宁夏回族自治区卫生健康委科研课题(编号:2022-NWKY-072) （编号:2022-NWKY-072）
