天津中医药大学学报2026，Vol.45Issue(1)：119-128,10.DOI:10.11656/j.issn.1673-9043.2026.01.16
中医药调控AMPK信号通路治疗冠心病研究进展
Research progress on traditional Chinese medicine regulating AMPK signaling pathway for coronary heart disease
摘要
Abstract
The incidence of coronary atherosclerotic heart disease(CHD)is showing a trend toward affecting younger individuals and has become one of the diseases with the highest mortality rates in China.Current research indicates that AMP-activated protein kinase(AMPK)participates in the entire process of CHD occurrence and development by influencing biological processes such as cardiomyocyte injury,death,proliferation,and transformation.In recent years,studies on traditional Chinese medicine(TCM)in cardiovascular diseases have demonstrated its favorable clinical efficacy and minimal adverse reactions.Concurrently,numerous experimental studies have been conducted on TCM regulating the AMPK signaling pathway for CHD treatment.The article reviews and summarizes recent relevant literature,outlines the role of AMPK in the pathogenesis of CHD,and summarizes progress of in vivo and in vitro experimental research on TCM regulation of AMPK and its related signaling pathways,aiming to provide insights for a deeper understanding of CHD pathogenesis and TCM treatment strategies.关键词
冠状动脉粥样硬化性心脏病/腺苷酸活化蛋白激酶/动脉粥样硬化/中药调控Key words
coronary atherosclerotic heart disease/AMP-activated protein kinase/atherosclerosis/traditional Chinese medicine regulation分类
医药卫生引用本文复制引用
吕鑫良,闫景顺,李雯玥,赵美,张红霞,朱林平..中医药调控AMPK信号通路治疗冠心病研究进展[J].天津中医药大学学报,2026,45(1):119-128,10.基金项目
第五批全国中医临床优秀人才研修项目[国中医药人教函(2022)1号] （2022）
天津市卫生健康委员会中医经典传承高级人才研修项目(津卫中便函[2022]75). （津卫中便函[2022]75）
