可控制备介孔碳球调控用于增强光热-化疗协同治疗
Engineered mesoporous carbon spheres with tailored pore structures for improved photothermal-chemotherapy
摘要
Abstract
Carbon-based materials have gained significant at-tention in anticancer treatment because of their exceptional biocompatibility,yet critical challenges persist in establishing definitive correlations between their porous structures and functional performance.We report the use of a silica template to guide pore formation in the design of mesoporous carbon spheres(mC)with tailored pore structures for improved com-bined photothermal-chemotherapy.The mesopore size of mC has been adjusted by kinetic control of the resin polymeriza-tion and silica hydrolysis.Structural characterization showed that 4.4 nm mesopores enabled an exceptional gemcitabine loading of 228 mg g-1 and a sustained pH/thermal dual-re-sponsive release with>70%drug release under near-infrared(NIR)irradiation.Finite element analysis demonstrated pore size-dependent heat transfer dynamics,with the improved mC achieving a superior photothermal conversion efficiency of 62%by a combination of N-doping and defect engineering.In vitro evaluations confirmed outstanding biocompatibility with>95%cell viability at 200 μg mL-1 and potent tumor suppression in pancreatic and biliary cancer models with an～5%cell viability at 25 μg mL-1 where combined therapy showed a 3.7-fold in-creased cytotoxicity over monotherapy.The improved structure of mC facilitated cascade therapeutic effects with enhanced tu-mor permeability derived from NIR-triggered hyperthermia and prolonged therapeutic exposure due to pH-responsive drug re-lease.This pore engineering strategy establishes a structure-function process for next-generation theranostic platforms,address-ing the critical limitations of conventional pancreatic and biliary cancer therapies through spatiotemporal control of multimodal treatment.关键词
介孔碳球/孔结构/光热效应/药物递送系统/化疗Key words
Mesoporous carbon spheres/Pore architectures/Photothermal/Drug delivery system/Chemotherapy分类
化学化工引用本文复制引用
刘鹏翔,杜娟,陈爱兵,侯森林..可控制备介孔碳球调控用于增强光热-化疗协同治疗[J].新型炭材料（中英文）,2026,41(1):222-233,12.基金项目
This work was supported by the National Natur-al Science Foundation of China(U23A20573,U23A20140),the Hebei Natural Science Foundation(B2024208091),S&T Program of Hebei(24465201D,242Q4301Z,236Z4306G),Huang-jin-tai plan project of Hebei provincial department of education(HJZD202512),Shijiazhuang Basic Research Project of Universities in Hebei Province(241790977A),the University level Graduate Innovation Funding Project of Hebei Medical University in 2024(XCXZZB202412).国家自然科学基金(U23A20573、U23A20140) （U23A20573,U23A20140）
河北省自然科学基金(B2024208091) （B2024208091）
河北省科技计划项目(24465201D、242Q4301Z、236Z4306G) （24465201D、242Q4301Z、236Z4306G）
河北省教育厅黄金台计划项目(HJZD202512) （HJZD202512）
河北省高校基础研究项目(241790977A) （241790977A）
河北医科大学研究生创新资助项目(XCXZZB202412). （XCXZZB202412）
