新医学2026，Vol.57Issue(2)：184-195,12.DOI:10.12464/j.issn.0253-9802.2025-0342
基于鼻腔分泌物细胞因子谱的变应性鼻炎疗效客观评估体系构建:一项范围综述
Developing an objective evaluation system based on cytokine profile in nasal secretions for allergic rhinitis treatment outcomes:a scoping review
摘要
Abstract
Objective To analyze the characteristics of cytokine profile changes in nasal secretions of allergic rhinitis(AR)patients receiving different treatments,with the aim of informing an objective,biomarker-based system for clinical efficacy assessment and guiding future research and policy development.Methods To explore objective evaluation indicators,this study conducted a comprehensive search of the studies related to cytokine detection and analysis of in nasal secretions in databases such as PubMed,Web of Science,CNKI and Wanfang Data,covering the period from July 1,2015 to July 1,2025.Results 118 studies met the inclusion criteria.Across multiple investigations,the levels of Th2-related cytokines consistently decreased after treatment,whereas those of Th1-related cytokines generally increased.Conclusions Th1-and Th2-related cytokines in nasal secretions can serve as an objective criterion for evaluating therapeutic efficacy,which can be used in subsequent related studies.关键词
变应性鼻炎/鼻腔分泌物/细胞因子/治疗/范围综述Key words
Allergic rhinitis/Nasal secretion/Cytokine/Treatment/Scoping review引用本文复制引用
李晨曦,沈暘,张小玲,刘煜川,卢韬,杨玉成..基于鼻腔分泌物细胞因子谱的变应性鼻炎疗效客观评估体系构建:一项范围综述[J].新医学,2026,57(2):184-195,12.基金项目
2023年超声医学工程国家重点实验室开放课题(2023KFKT001) （2023KFKT001）
2024年重庆市科卫联合医学科研项目(2024DBXM007) （2024DBXM007）
2024年重庆市研究生科研创新项目(CYS240296) （CYS240296）
