中草药2026，Vol.57Issue(4)：1506-1519,14.DOI:10.7501/j.issn.0253-2670.2026.04.026
石菖蒲及其活性成分防治阿尔茨海默病研究进展
Research progress on Acori Tatarinowii Rhizoma and its active constituents in prevention and treatment of Alzheimer's disease
摘要
Abstract
Alzheimer's Disease(AD)is a chronic neurodegenerative disorder characterized by a complex pathogenesis and a lack of effective clinical treatments.Shichangpu(Acori Tatarinowii Rhizoma)is the most commonly used single herb in clinical practice for the prevention and management of AD,recognized for its cognitive-enhancing and phlegm-resolving properties.By integrating advances in research on AD pathological mechanisms,this study synthesizes current knowledge regarding the active components of Acori Tatarinowii Rhizoma—including volatile components,alkaloids,organic acids,and terpenes—and their mechanisms of action in AD prevention and treatment.Evidence indicates that Acori Tatarinowii Rhizoma and its bioactive constituents exert anti-AD effects through multiple pathways,such as suppressing neuroinflammation,inhibiting oxidative stress,enhancing cholinergic function,and restoring blood-brain barrier integrity.These findings underscore its multi-component,multi-target therapeutic potential in AD intervention.This review provides a theoretical basis for the rational clinical application of Acori Tatarinowii Rhizoma and offers new perspectives for elucidating its modern pharmacological mechanisms.关键词
石菖蒲/阿尔茨海默病/活性成分/Aβ沉积/Tau蛋白过度磷酸化/神经炎症/氧化应激/细胞自噬/胆碱能系统功能障碍/钙稳态失调/血脑屏障Key words
Acori Tatarinowii Rhizoma/Alzheimer's disease/active ingredient/Aβ deposition/Tau hyperphosphorylation/neuroinflammation/oxidative stress/autophagy/cholinergic dysfunction/calcium homeostasis disruption/blood-brain barrier分类
医药卫生引用本文复制引用
杨鑫,马慧芬,谢治深,郭艺青,苏运芳,邵思迈,张振强,曹兵..石菖蒲及其活性成分防治阿尔茨海默病研究进展[J].中草药,2026,57(4):1506-1519,14.基金项目
国自然科学基金资助项目(82274612) （82274612）
国自然科学基金资助项目(82305087) （82305087）
国自然科学基金资助项目(82575183) （82575183）
中国博士后科学基金资助项目(2025M783967) （2025M783967）
河南省重点研发(231111312900) （231111312900）
河南省中医药科研专项(2025ZY3153) （2025ZY3153）
