中草药2026，Vol.57Issue(4)：1546-1558,13.DOI:10.7501/j.issn.0253-2670.2026.04.030
黄连在治疗炎症性肠病中的作用机制和应用研究进展
Research progress on mechanism and application of Coptidis Rhizoma in treatment of inflammatory bowel disease
摘要
Abstract
Inflammatory bowel disease(IBD)is a chronic,recurrent,non-specific gastrointestinal disease with an unclear pathogenesis,and there is no curative treatment at present.As a multi-component natural traditional Chinese medicine,Coptidis Rhizoma shows the advantages of multi-target and multi-pathway regulation in the treatment of IBD with its rich chemical composition and unique pharmacological activity.Its core active ingredients are isoquinoline alkaloids,including berberine,coptisine,palmatine,berberrubine,etc.,supplemented by flavonoids,lignans,organic acids,polysaccharides,terpenoids and other components,which have the effect of clearing heat and drying dampness,purgingfire and removing toxin.Modern pharmacological studies have confirmed that Coptidis Rhizoma and its active components exert therapeutic effects on IBD through multiple mechanisms,including antioxidative stress,anti-inflammatory,immunomodulatory,intestinal mucosal barrier protection,regulation of intestinal flora,glucose metabolism modulation,and cholinergic system regulation.This review summarizes the recent advances in the mechanisms and applications of Coptidis Rhizoma and its active ingredients in the treatment of IBD,providing a reference for the development of standardized clinical preparations of Coptidis Rhizoma.关键词
黄连/炎症性肠病/黏膜屏障/肠道菌群/小檗碱/黄连碱/巴马汀/小檗红碱Key words
Coptidis Rhizoma/inflammatory bowel disease/mucosal barrier/intestinal microflora/berberine/coptisine/palmatine/berberrubine分类
医药卫生引用本文复制引用
崔西,李航航,翟睿,刘翠翠,史树勋..黄连在治疗炎症性肠病中的作用机制和应用研究进展[J].中草药,2026,57(4):1546-1558,13.基金项目
国家医疗质量循证管理持续改进研究项目(YLZLXZ22G029) （YLZLXZ22G029）
甘肃中医药大学联合科研基金项目(HXLH-XTCX01) （HXLH-XTCX01）
兰州市科技发展指导性计划项目(2024-9-83) （2024-9-83）
甘肃省高校教师创新基金项目(2025B-114) （2025B-114）
