摘要
Abstract
Objective To investigate the impact of serum cyclophilin A(CyPA)and interleukin-6(IL-6)on stent thrombosis in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI)and their predictive value for thrombosis.Methods A total of 122 AMI patients who underwent PCI at the First People's Hospital of Huzhou City from January 2021 to June 2023 were enrolled.Serum levels of CyPA and IL-6 were measured 2 hours post-PCI.All patients were followed up for 1 year to document stent thrombosis events.Multivariate Logistic regression analysis was performed to evaluate the association between serum CyPA,IL-6 levels and stent thrombosis after PCI.Receiver operating characteristic(ROC)curve analysis was conducted to assess the predictive value of CyPA and IL-6 for post-PCI stent thrombosis in AMI patients.Results The patients were followed up for one year.Among the 122 patients,24 cases developed stent thrombosis after PCI and were classified as the occurrence group,while the remaining 98 cases were included in the non-occurrence group.There were statistically significant differences in the proportions of diabetes and preoperative cardiac dysfunction between the occurrence group and the non-occurrence group(χ2=4.245,8.421;P<0.05).The occurrence group demonstrated significantly higher serum CyPA and IL-6 levels both at 2h post-PCI and during follow-up compared to the non-occurrence group,and the differences were statistically significant(t=4.887,16.268,3.868,50.747;P<0.05).Multivariate Logistic regression analysis identified diabetes,preoperative cardiac dysfunction,elevated serum CyPA and IL-6 as risk factors for stent thrombosis after PCI in AMI patients(OR=14.906,17.802,1.851,1.196;P<0.05).The ROC curve analysis revealed that the areas under the curve(AUCs)of serum CyPA and IL-6 predicting stent thrombosis in AMI patients after PCI alone were both greater than 0.7,while the AUC of combined prediction was greater than 0.8,indicating superior predictive value.Conclusion Elevated levels of serum CyPA and IL-6 are risk factors for stent thrombosis in AMI patients after PCI,and can be clinically used as predictive indicators for stent thrombosis in AMI patients after PCI.关键词
急性心肌梗死/经皮冠状动脉介入治疗/支架内血栓形成/亲环素A/白细胞介素-6Key words
Acute myocardial infarction/Percutaneous coronary intervention/Stent thrombosis/Cyclophilic A/Interleukin-6
