中国肛肠病杂志2026，Vol.46Issue(2)：39-43,5.
基于子午流注理论择时隔药灸脐法治疗脾虚湿蕴证溃疡性结肠炎的临床研究
Clinical Study on Time-Selected Medicinal-Separated Umbilical Moxibustion in Treatment of Ulcerative Colitis of Spleen Deficiency and Dampness Retention Syndrome Based on Theory of Midnight-Noon Ebb-Flow
摘要
Abstract
Objective To explore the clinical efficacy and safety of time-selected medicinal-separated umbilical moxibustion in the treatment of ulcerative colitis(UC)of spleen deficiency and dampness retention syndrome based on the theory of midnight-noon ebb-flow.Methods A total of 90 UC patients of spleen defi-ciency and dampness retention syndrome who met the inclusion and exclusion criteria and were treated in the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from October 2024 to July 2025 were selected as the study objects.They were divided into group A(the mesalazine group),group B(the medicinal-separated umbilical moxibustion group)and group C(the medicinal-separated umbilical moxibustion at Si-time group)by random number table method,with 30 cases in each group.All three groups received 8 weeks of treatment.The clinical efficacy,scores of traditional Chinese medicine(TCM)syndrome and modified Mayo score before and after treatment,serum levels of inflammatory factors including tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10),as well as the incidence of adverse reactions were compared among the three groups.Results The total effective rates of group A,group B and group C were 86.67%,90.00%and 93.33%respectively,showing an increasing trend,but the difference was not statistically significant(P>0.05).In terms of improvement of TCM syndromes,the total syndrome score,scores of limb lassitude and poor appetite in group C were superior to those in group B and group A(P<0.05).The score of dull abdomi-nal pain in group C was superior to that in group A(P<0.05),while there was no significant difference com-pared with group B(P>0.05).After treatment,the modified Mayo score and serum level of TNF-α decreased sequentially in group A,group B and group C,while the level of IL-10 increased sequentially.Inter-group comparison showed that group B and group C were superior to group A(P<0.05),but there was no sig-nificant difference between group B and group C(P>0.05).No severe adverse reactions occurred in the three groups,indicating good safety.Conclusion Medicinal-separated umbilical moxibustion has a definite cura-tive effect in the treatment of UC of spleen deficiency and dampness retention syndrome.In particular,time-selected medicinal-separated umbilical moxibustion based on the theory of midnight-noon ebb-flow has a better effect in improving limb lassitude and poor appetite,with good safety and higher promotion value.关键词
溃疡性结肠炎/子午流注/隔药灸脐/脾虚湿蕴证Key words
Ulcerative colitis/Theory of midnight-noon ebb-flow/Medicinal-separated umbilical moxibus-tion/Spleen deficiency and dampness retention syndrome引用本文复制引用
王逸,邓永文,张全辉,孙伟康..基于子午流注理论择时隔药灸脐法治疗脾虚湿蕴证溃疡性结肠炎的临床研究[J].中国肛肠病杂志,2026,46(2):39-43,5.基金项目
江西省研究生创新专项资金项目(YC2024-S737) （YC2024-S737）
