心理科学进展2026，Vol.34Issue(3)：499-514,16.DOI:10.3724/SP.J.1042.2026.0499
前额叶-海马-内侧隔核环路的theta-gamma相位幅值耦合:跨脑区协同与工作记忆调控机制
Theta-gamma phase-amplitude coupling in the prefrontal-hippocampal-medial septal circuit:Mechanisms of cross-regional coordination and working memory regulation
摘要
Abstract
Working memory,as the foundation of higher-order cognitive functions,depends on the dynamic coordination within the Prefrontal-Hippocampal-medial Septal neural circuit.Within this circuit,θ-γ phase-amplitude coupling(Theta-gamma phase-amplitude coupling,TG-PAC)serves as a critical mechanism for cross-regional information integration.This article systematically elucidates the central regulatory role of TG-PAC in working memory within the Prefrontal-Hippocampal-medial Septal network.Research has demonstrated that the prefrontal cortex sustains information representations in working memory through persistent neural activity.Its θ rhythm(4～8 Hz)modulates γ rhythm(30～80 Hz)via phase coordination,forming temporal windows essential for cognitive control.As the hub for spatial information processing,the hippocampal supports spatial navigation and the binding of working memory through θ-γ nested coding,where the coupling strength between local γ activity and the θ rhythm could predict memory capacity and behavioral performance.Cross-regional coupling between the prefrontal θ phase and hippocampal gamma amplitude establishes a dynamic interface for cognitive control and memory storage,ensuring the precise execution of working memory tasks.The medial septum,acting as a crucial relay node,regulates the intensity and spatiotemporal characteristics of TG-PAC through its cholinergic,GABAergic,and glutamatergic neurons by modulating hippocampus θ rhythms,thereby influencing working memory efficiency.Notably,abnormalities in TG-PAC are closely associated with cognitive impairments in schizophrenia and Alzheimer's disease,highlighting its clinical value as a potential biomarker and neuromodulation target.This study innovatively integrates the tripartite Prefrontal-Hippocampal-medial Septal circuit coupling,and prospect future research to integrate multimodal imaging,cell-specific regulation,and computational modeling,so as to promote new intervention strategies for cognitive disorders based on neural oscillation coupling.关键词
工作记忆/theta-gamma相位幅值耦合/交叉节律耦合/前额叶/海马/内侧隔核Key words
working memory/θ-γ phase amplitude coupling/cross-frequency coupling/prefrontal cortex/hippocampus/medial Septal neural分类
社会科学引用本文复制引用
张秋霞,陈伟海..前额叶-海马-内侧隔核环路的theta-gamma相位幅值耦合:跨脑区协同与工作记忆调控机制[J].心理科学进展,2026,34(3):499-514,16.基金项目
国家自然科学基金面上项目(32371133) （32371133）
西南大学中央高校基本科研业务费专项资金项目资金(SWU2409103)资助. （SWU2409103）
