眼科新进展2026，Vol.46Issue(2)：149-153,5.DOI:10.13389/j.cnki.rao.2026.0026
视网膜色素变性中有氧糖酵解与乳酸代谢的微环境调控
Microenvironmental regulation of aerobic glycolysis and lactate metabolism in retinitis pigmentosa
摘要
Abstract
Retinitis pigmentosa(RP)is characterized by progressive dysfunction of photoreceptor(PR)cells and reti-nal pigment epithelium(RPE)cells,with the unique metabolic characteristics of PR cells and RPE cells playing a key role.RPE cells supply glucose from the choroidal cycle to PR cells,while rod cells assist cone cells and both produce lactate to meet the energy needs of RPE cells.Lactate can inhibit glycolysis in RPE cells,allowing more glucose to reach PR cells.Mu-tations in RP-related genes lead to impaired function of rod cells,reduced lactate production,and insufficient energy supply to RPE cells.In this case,RPE cells will consume additional glucose to meet their metabolic needs,resulting in a decrease in glucose transport to PR cells.Additionally,impaired RPE cell function can also affect glucose transport,ultimately leading to degeneration of both PR and RPE cells.This article reviews the glycolysis-lactate metabolic axis in the homeostasis of PR cells and RPE cells,as well as its importance in the outer retinal metabolic ecosystem and the progression of RP disease.关键词
视网膜色素变性/乳酸/有氧糖酵解/光感受器/视网膜色素上皮Key words
retinitis pigmentosa/lactate/aerobic glycolysis/photoreceptor/retinal pigment epithelium分类
医药卫生引用本文复制引用
孟佳,蔡善君..视网膜色素变性中有氧糖酵解与乳酸代谢的微环境调控[J].眼科新进展,2026,46(2):149-153,5.基金项目
国家自然科学基金面上项目(编号:31871261) （编号:31871261）
贵州省基础研究计划项目[编号:黔科合基础-ZK(2023)一般529] （2023）
贵州省科技支撑计划项目[编号:黔科合支撑(2023)一般265] （2023）
