眼科新进展2026，Vol.46Issue(2)：154-158,5.DOI:10.13389/j.cnki.rao.2026.0027
环化酸鸟苷-腺苷酸合成酶-干扰素基因刺激因子通路在眼部疾病中作用的研究进展
Research progress on the role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in eye diseases
摘要
Abstract
Pathogen infection and non-pathogenic factors can trigger immune responses,leading to eye inflammation.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING)pathway is a recently discovered inflammatory signaling pathway that recognizes double-stranded DNA as an activation sig-nal to promote the expression of downstream cytokines in inflammatory or autoimmune responses.More and more evidence has shown that the cGAS-STING signaling pathway plays a key role in mediating ocular inflammation and inflammatory dis-eases,including dry eye,keratitis,uveitis,glaucoma,diabetic retinopathy,and age-related macular degeneration.This article reviews the research on the role of the cGAS-STING pathway in eye diseases,in order to provide guidance for the pathogen-esis and molecular targets of eye diseases.关键词
环化酸鸟苷-腺苷酸合成酶-干扰素基因刺激因子/信号转导通路/眼部炎症/角膜炎/糖尿病视网膜病变/年龄相关性黄斑变性/葡萄膜炎Key words
cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes/sig-nal transduction pathway/ocular inflammation/keratitis/diabetic retinopathy/age-related macular degeneration/uveitis分类
医药卫生引用本文复制引用
王烽,赖江峰,曹玲英,邵毅..环化酸鸟苷-腺苷酸合成酶-干扰素基因刺激因子通路在眼部疾病中作用的研究进展[J].眼科新进展,2026,46(2):154-158,5.基金项目
国家自然科学基金项目(编号:82160195) （编号:82160195）
