亚太传统医药2026，Vol.22Issue(2)：202-206,5.DOI:10.11954/ytctyy.202602037
基于"土壅木郁"理论探讨Sestrin2通路防治肥胖2型糖尿病
Exploring the Sestrin2 Pathway Against Obese T2DM Based on the Theory of"Tu Yong Mu Yu"
摘要
Abstract
Based on Tu Yong Mu Yu theory to explore the mechanism of action of the stress-induced protein 2(Sestrin2),Kelch-like ECH-associated protein 1(Keap1),and nuclear factor erythroid 2-related factor 2(Nrf2)signa-ling pathways in obese type 2 diabetes mellitus(T2DM).Endoplasmic reticulum stress(ERS)is a key pathological link connecting obesity and T2DM,while the Sestrin2/Keap1/Nrf2(reticulum stress,ERS)is a key pathological link connecting obesity,and T2DM.The Sestrin2/Keap1/Nrf2 pathway activates antioxidant stress,improves ERS and lipid metabolism disorders,restores pancreatic β-cell function,and alleviates insulin resistance(IR).The"Tu Yong Mu Yu"theory aligns closely with the modern medical mechanisms of ERS.Methods such as strengthening the spleen and re-moving dampness,and regulating the liver and clearing turbidity may upregulate Sestrin2 expression,inhibit Keap1 ac-tivity,activate the Nrf2 nuclear transcription factor,alleviate ERS-induced IR,and delay the progression of T2DM.This study provides a theoretical basis for traditional Chinese medicine to regulate the Sestrin2/Keap1/Nrf2 pathway to im-prove obese T2DM.关键词
土壅木郁/Sestrin2/Keap1/Nrf2/肥胖/2型糖尿病Key words
Tu Yong Mu Yu/Sestrin2/Keap1/Nrf2/Obese/Type 2 Diabetes Mellitus分类
医药卫生引用本文复制引用
马永胜,房国伟,曹洪叶,张辰达,黄延芹..基于"土壅木郁"理论探讨Sestrin2通路防治肥胖2型糖尿病[J].亚太传统医药,2026,22(2):202-206,5.基金项目
国家自然科学基金面上项目(81974562) （81974562）
山东省泰山学者青年专家计划项目(tsqn202211354) （tsqn202211354）
山东省自然科学基金项目(ZR2024MH245) （ZR2024MH245）
钱秋海全国名老中医药专家传承工作室(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
山东省重点研发计划(CXPT147) （CXPT147）
山东省重点实验室(PKL2024C23) （PKL2024C23）
