云南民族大学学报（自然科学版）2026，Vol.35Issue(1)：52-56,76,6.DOI:10.3969/j.issn.1672-8513.2026.01.007
金荞麦的化学成分及α-葡萄糖苷酶抑制活性研究
Chemical constituents from Fagopyrum dibotrys and their α-glucosidase inhibitory activity
摘要
Abstract
In order to study the α-glucosidase inhibitory activity of the crude extract and monomeric compounds of Fagopyrum dibotrys,the ethanol extract of Fagopyrum dibotrys was extracted with different solvents and the α-glucosidase inhibitory activity of different extraction parts was evaluated.Then,a variety of chromatographic techniques were used to separate and purify the n-butanol fraction with significant α-glucosidase inhibitory activity.Eleven compounds were isolated and analyzed by modern spectroscopic techniques.The structure of the compound was identified as luteolin(1),loganin acid(2),hesperidin(3),(-)-epicatechin(4),(+)-catechin(5),quercetin(6),kaempferol(7),rutin(8),diosmetin(9),polydatin(10),α-terthiophene(11).Among them,compounds 2,3,10 and 11 were isolated from Fagopyrum dibotrys for the first time.Compounds 1,4,5 and 6 exhibited significant α-glucosidase inhibitory activities with IC50 values of(6.91±0.38),(14.93±0.35),(15.06±0.25)and(7.04±2.62)μmol/L,respectively.关键词
金荞麦/化学成分/降糖活性/α-葡萄糖苷酶Key words
Fagopyrum dibotrys/chemical constituents/hypoglycemic activity/α-glucosidase分类
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原文毅,赵霞,杨凤仙..金荞麦的化学成分及α-葡萄糖苷酶抑制活性研究[J].云南民族大学学报（自然科学版）,2026,35(1):52-56,76,6.基金项目
国家自然科学基金(32301271). （32301271）
