云南民族大学学报（自然科学版）2026，Vol.35Issue(1)：77-85,116,10.DOI:10.3969/j.issn.1672-8513.2026.01.010
丁香脂素对膝骨关节炎的治疗作用及机制研究
Investigating the therapeutic effects and mechanisms of syringaresinol on knee osteoarthritis via the TLR4/NF-κB signaling pathway
摘要
Abstract
This study investigated the chondroprotective effects of syringaresinol(Syr)on rats with knee osteoarthritis(KOA)and its regulatory mechanism via the TLR4/NF-κB pathway.A KOA model was established in SD rats using the modified Hulth method.Thirty rats were randomly divided into a sham-operated group,a model group,a positive drug group(indomethacin,10 mg/kg),and low-and high-dose Syr groups(25 and 50 mg/kg),with six rats in each group.The results showed that compared with the model group,Syr intervention significantly improved motor function(P＜0.01),reduced serum levels of IL-1β and MMP13(P＜0.01),and alleviated cartilage pathological damage.Western blot and real-time quantitative polymerase chain reaction confirmed that Syr dose-dependently downregulated the protein and mRNA expression of TLR4 and P-NF-κB in cartilage tissue(P＜0.01),while significantly increasing the expression of type Ⅱ collagen(P＜0.01).Mechanistic studies indicated that Syr effectively alleviated joint inflammation and delayed cartilage matrix degradation by inhibiting the activation of the TLR4/NF-κB signaling pathway.These findings provide a theoretical basis for the clinical application of syringaresinol in the prevention and treatment of KOA and for the modernization of Chinese medicine.关键词
丁香脂素/膝骨性关节炎/关节功能/软骨保护/TLR4/NF-κB信号通路Key words
syringaresinol/knee osteoarthritis/joint function/cartilage protection/TLR4/NF-κB signaling pathway分类
医药卫生引用本文复制引用
王若秦,陈飞飞,郑永智,张果,贾洋洋..丁香脂素对膝骨关节炎的治疗作用及机制研究[J].云南民族大学学报（自然科学版）,2026,35(1):77-85,116,10.基金项目
河南省高等学校重点科研项目(23A360023). （23A360023）
