中国临床药理学杂志2025，Vol.41Issue(24)：3477-3481,5.DOI:10.13699/j.cnki.1001-6821.2025.24.005
2019～2023年新疆地区肺炎克雷伯菌耐药性监测
Surveillance of antimicrobial in Klebsiella pneumoniae in Xinjiang region from 2019 to 2023
热那古·艾山 1陈娜 2季萍2
作者信息
- 1. 新疆维吾尔自治区喀什地区第二人民医院检验科 新疆维吾尔自治区喀什 844000
- 2. 新疆医科大学第一附属医院检验科 新疆维吾尔自治区乌鲁木齐 830054
- 折叠
摘要
Abstract
Objective To understand the distribution and antibiotic resistance changes of clinical isolated Klebsiella pneumoniae in Xinjiang from 2019 to 2023,and provide a basis for the rational use of antibiotics in clinical practice.Methods Clinical isolates from Xinjiang region between 2019 and 2023 were collectd and identified and subjected to drug sensitivity tests using the fully automated bacterial identification analyzer VITEK-2 compact and VITEK-MS,supplemented by the K-B paper method.Results Over the course of 5 years,a total of 72 678 strains of Klebsiella pneumoniae were detected,among which 19 061 were extended-spectrum β-lactamases(ESBLs)producing strains,accounting for a detection rate of 26.23％.The strains mainly come from sputum,urine,blood,etc.The top three departments in terms of strain distribution were the intensive care medicine,respiratory medicine,and pediatrics.The resistance rates of Klebsiella pneumoniae to third-generation cephalosporins ceftriaxone and ceftazidime were 21.42％and 15.73％,respectively.The resistance rates to carbapenems ranged from 6.82％to 7.48％,and the resistance rate to amikacin was 4.15％.Conclusion Klebsiella pneumoniae has become one of the most common pathogenic bacteria in clinical practice.The resistance of Klebsiella pneumoniae detected in Xinjiang is not optimistic.In order to improve the treatment effect of antibiotics,the resistance of antibiotics in the local area should be continuously monitored,and antibiotics should be selected reasonably based on drug sensitivity results.关键词
抗菌药物/肺炎克雷伯菌/耐药性/医院感染Key words
antibiotics/Klebsiella pneumoniae/drug resistance/nosocomial infection分类
医药卫生引用本文复制引用
热那古·艾山,陈娜,季萍..2019～2023年新疆地区肺炎克雷伯菌耐药性监测[J].中国临床药理学杂志,2025,41(24):3477-3481,5.
