中国临床药理学杂志2025，Vol.41Issue(24)：3518-3523,6.DOI:10.13699/j.cnki.1001-6821.2025.24.011
ACOT8泛癌分析及其在前列腺癌患者预后中的潜在作用
ACOT8 pan-cancer analysis and its potential role in the prognosis of prostate cancer patients
摘要
Abstract
Objective To clarify the role of acyl-CoA thioesterase 8(ACOT8)across cancers,particularly its prognostic value,and its links to ferroptosis and the immune microenvironment in prostate cancer(PCa).Methods Using data from The Cancer Genome Atlas(TCGA),R software was used to analyze the gene differential expression of ACOT8 in pan-cancer and the correlation between prognosis.The single sample gene set enrichment analysis(ssGSEA),cell-type identification by estimating relative subsets of known RNA transcripts(CIBERSORT)and tumor immune dysfunction and exclusion(TIDE)algorithms were employed to assess correlations with ferroptosis and immune cell infiltration.Results ACOT8 was upregulated in 11 cancers and high expression predicted poor survival,most significantly in PCa.In PCa,ACOT8 expression was negatively correlated with ferroptosis activity and positively correlated with immunosuppressive cells.Conclusion ACOT8 is a poor prognostic marker in PCa,potentially by inhibiting ferroptosis and promoting an immunosuppressive microenvironment.关键词
酰基辅酶A硫酯酶8/预后/铁死亡/免疫微环境/泛癌分析Key words
acyl-CoA thioesterase 8/prognosis/ferroptosis/immune microenvironment/pan-cancer analysis分类
医药卫生引用本文复制引用
张默,陈洁,薛瑞芬,戎卓娜..ACOT8泛癌分析及其在前列腺癌患者预后中的潜在作用[J].中国临床药理学杂志,2025,41(24):3518-3523,6.基金项目
北京市自然科学基金资助项目(L248076) （L248076）
