中国临床药理学杂志2025，Vol.41Issue(24)：3530-3535,6.DOI:10.13699/j.cnki.1001-6821.2025.24.013
主动脉瓣机械瓣膜置换术后合并下肢动脉栓塞抗凝治疗的药学监护
Pharmaceutical care for anticoagulation therapy following mechanical aortic valve replacement complicated by lower extremity arterial embolism
张微微 1佘康 2杨敏 2王梓凝3
作者信息
- 1. 北京大学第一医院 药剂科,北京 100034||清华大学北京清华长庚医院临床药学科,北京 102218||清华大学化学工程系,北京 100084
- 2. 北京大学第一医院 介入血管外科,北京 100034
- 3. 北京大学第一医院 药剂科,北京 100034
- 折叠
摘要
Abstract
Objective To provide anticoagulation recommendations and optimize pharmacotherapy for a patient with lower extremity arterial embolism following aortic valve replacement by integrating pharmacogenomics and drug-drug interactions with medication education.Methods A clinical pharmacist participated in the anticoagulation therapy and medication monitoring for a patient who underwent emergency surgery due to lower extremity arterial embolism after mechanical aortic valve replacement.Based on an analysis of the patient's individual condition and clinical characteristics,and with reference to guidelines and evidence-based literature,the clinical pharmacist guided the perioperative anticoagulation regimen.Factors influencing the effect of warfarin were also analyzed to optimize its dosage.Results The patient's lower extremity arterial embolism improved,and the patient was discharged with favorable follow-up outcomes.Conclusion This case provides a reference for clinical pharmacists in managing anticoagulation therapy for patients with lower extremity arterial embolism after mechanical heart valve replacement.关键词
华法林/主动脉瓣机械瓣膜置换/下肢动脉栓塞/药学监护Key words
warfarin/mechanical prosthetic aortic valve replacement/lower extremity arterial embolism/pharmaceutical care分类
医药卫生引用本文复制引用
张微微,佘康,杨敏,王梓凝..主动脉瓣机械瓣膜置换术后合并下肢动脉栓塞抗凝治疗的药学监护[J].中国临床药理学杂志,2025,41(24):3530-3535,6.
