中国普通外科杂志2025，Vol.34Issue(12)：2605-2611,7.DOI:10.7659/j.issn.1005-6947.250569
中性粒细胞-单核细胞/淋巴细胞比值与颈动脉粥样硬化斑块稳定性的相关性分析
Association between the neutrophil-monocyte to lymphocyte ratio and carotid atherosclerotic plaque stability
梁子舜 1李志高 2蔡晶 2唐晨 2倪茜 1王庆贺 2齐佳霖 1乔彤1
作者信息
- 1. 南京中医药大学鼓楼临床医学院 血管外科,江苏 南京 210008
- 2. 南京大学医学院附属鼓楼医院 血管外科,江苏 南京 210008
- 折叠
摘要
Abstract
Background and Aims:Plaque instability is a major pathological determinant of ischemic stroke in patients with carotid atherosclerosis,in which inflammation plays a pivotal role.The neutrophil-plus-monocyte to lymphocyte ratio(NMLR)is a novel systemic inflammatory marker,but its association with carotid plaque stability remains unclear.This study aimed to investigate the relationship between NMLR and carotid plaque stability and to evaluate its predictive value.
Methods:A total of 211 patients with carotid artery stenosis who underwent carotid endarterectomy were retrospectively enrolled.According to postoperative pathological assessment,patients were classified into a vulnerable plaque group(n=113)and a stable plaque group(n=98).Clinical characteristics and preoperative laboratory parameters were collected,and NMLR and neutrophil-to-lymphocyte ratio(NLR)were calculated.Multivariate Logistic regression analysis was performed to identify independent predictors of plaque vulnerability.Receiver operating characteristic(ROC)curves were used to assess the predictive performance of NMLR and NLR.
Results:Patients with vulnerable plaques had significantly higher NMLR and NLR levels than those with stable plaques(both P<0.001).Multivariate Logistic regression analysis identified previous stroke history(OR=4.59,95%CI=2.22-9.50),NMLR(OR=7.07,95%CI=3.71-13.48),and NLR(OR=5.89,95%CI=3.09-11.25)as independent predictors of plaque vulnerability.ROC curve analysis demonstrated that NMLR yielded an AUC of 0.83 with an optimal cutoff value of 2.71,showing a sensitivity of 86.7%and a specificity of 69.7%.The AUC of NLR was 0.79,with comparable predictive performance.
Conclusion:NMLR,an inflammatory marker integrating the pro-inflammatory effects of neutrophils and monocytes and the protective role of lymphocytes,is closely associated with carotid plaque instability and exhibits good predictive value.It may serve as a convenient and effective tool for risk stratification and stroke prevention in patients with carotid atherosclerosis.关键词
颈动脉狭窄/颈动脉内膜切除术/斑块,动脉粥样硬化/中性粒细胞-单核细胞/淋巴细胞比值Key words
Carotid Stenosis/Endarterectomy,Carotid/Plaque,Atherosclerotic/Neutrophil-Monocyte to Lymphocyte Ratio分类
医药卫生引用本文复制引用
梁子舜,李志高,蔡晶,唐晨,倪茜,王庆贺,齐佳霖,乔彤..中性粒细胞-单核细胞/淋巴细胞比值与颈动脉粥样硬化斑块稳定性的相关性分析[J].中国普通外科杂志,2025,34(12):2605-2611,7.
