中国比较医学杂志2026，Vol.36Issue(1)：92-102,11.DOI:10.3969/j.issn.1671-7856.2026.01.010
肝郁证动物模型中枢生物学改变异同研究进展
Research progress on similarities and differences in central biological changes in animal models of liver depression syndrome
摘要
Abstract
Liver depression syndrome is commonly observed in various clinical diseases.Extensive studies have demonstrated that chronic stress serves as a primary trigger for liver depression syndrome,and its biological mechanisms are closely related to changes in the morphology and function of multiple central brain regions.The relevant evidence,however,remains scattered across numerous studies,necessitating further synthesis and review.This review accordingly summarizes the relationships between the pathogenesis of liver depression syndrome and morphological,functional,and molecular changes in brain regions,including the hippocampus,cortex,hypothalamus,locus coeruleus,and amygdala.Among these,the pathological changes in liver depression syndrome models are predominantly concentrated in the hippocampus and hypothalamus.However,distinct liver depression syndrome models exhibit variations in the affected brain regions.This review summarizes and explores the common biological alterations and specific differences among different liver depression syndrome models.The findings provide a foundation and direction for further research into the biological basis of liver depression syndrome and the identification of syndrome-specific targets.关键词
肝郁证/动物模型/大脑中枢/生物学机制Key words
liver depression/animal models/brain center/biological mechanisms分类
医药卫生引用本文复制引用
匡洛逸,罗紫龙,贾庆,王敏芝,杨铁柱,陈玉龙,吴耀松,刘燕..肝郁证动物模型中枢生物学改变异同研究进展[J].中国比较医学杂志,2026,36(1):92-102,11.基金项目
国家自然科学基金项目(82104717) （82104717）
河南省"双一流"创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-11) （HSRP-DFCTCM-2023-1-11）
河南省科技厅河南省重点研发与推广专项(科技攻关)(232102310443) （科技攻关）
河南省博士后资助项目(HN2024088) （HN2024088）
2024 年河南省科技研发计划联合基金(优势学科培育类)项目(242301420099). （优势学科培育类）
