中国比较医学杂志2026，Vol.36Issue(1)：103-113,11.DOI:10.3969/j.issn.1671-7856.2026.01.011
表观遗传学技术在脓毒症心肌损伤机制与治疗中的研究进展
Advances in epigenetic technologies for mechanistic and therapeutic research in sepsis-induced myocardial injury
摘要
Abstract
Sepsis-induced myocardial injury(SIMI)is a common and potentially fatal complication of sepsis.Its pathogenesis has not been fully elucidated,but involves multiple pathological processes,including excessive inflammatory response,mitochondrial dysfunction,apoptosis,and oxidative stress.Current clinical interventions primarily include fluid resuscitation,vasoactive agents,and anti-inflammatory therapies;however,their efficacy remains limited,and they fail to reverse pathological remodeling at the epigenetic level.This systematic review summarizes the result of studies on epigenetic modifications,including DNA methylation,histone modifications(acetylation,methylation),and non-coding RNA regulation,in relation to septic myocardial injury.The review aims to provide novel perspectives to aid in the early warning,diagnosis,treatment,and targeted drug development of SIMI,thereby improving the prognosis of patients with this condition.关键词
脓毒症心肌损伤/表观遗传学/DNA甲基化/组蛋白修饰/非编码核糖核酸Key words
sepsis-induced myocardial injury/epigenetics/DNA methylation/histone modifications/non-coding RNA分类
医药卫生引用本文复制引用
王晓璇,肖璐..表观遗传学技术在脓毒症心肌损伤机制与治疗中的研究进展[J].中国比较医学杂志,2026,36(1):103-113,11.基金项目
国家自然科学基金项目(82405123) （82405123）
河北省中医药管理局科研项目(T2025106) （T2025106）
天津中医药大学第一附属医院"拓新工程"基金项目(院201928). （院201928）
