中国现代医学杂志2026，Vol.36Issue(4)：91-96,6.DOI:10.3969/j.issn.1005-8982.2026.04.015
参松养心胶囊联合曲唑酮治疗稳定型心绞痛PCI术后慢性失眠患者的临床疗效研究
Clinical efficacy of Shensong Yangxin Capsules combined with trazodone in patients with chronic insomnia following percutaneous coronary intervention for stable angina pectoris
摘要
Abstract
Objective To investigate the clinical efficacy of Shensong Yangxin Capsules combined with trazodone in patients with chronic insomnia following percutaneous coronary intervention(PCI)for stable angina pectoris.Methods Eighty-four patients with stable angina undergoing PCI who developed postoperative chronic insomnia between April 2022 and March 2025 at Baoji People's Hospital were enrolled.Patients were randomly assigned to the observation group or the control group using a random number table,with 42 patients in each group.Both groups received standard postoperative management.The control group received conventional treatment supplemented with trazodone.The observation group was additionally given Shensong Yangxin Capsules.Sleep quality,inflammatory markers,myocardial injury indicators,polysomnography findings,and cardiovascular adverse events were compared between groups.Results The change in Pittsburgh Sleep Quality Index(PSQI)scores from baseline to post-treatment was greater in the observation group than in the control group(P<0.05).The pre-to-post treatment differences in interleukin-6,high-sensitivity C-reactive protein,and tumor necrosis factor-α levels were greater in the observation group than in the control group(P<0.05).The pre-to-post treatment differences in brain natriuretic peptide and heart-type fatty acid-binding protein levels were greater in the observation group than in the control group(P<0.05).The pre-to-post treatment differences in the number of awakenings,slow-wave sleep duration,and sleep latency were all greater in the observation group than in the control group(P<0.05).The overall incidence of cardiovascular adverse events was lower in the observation group than in the control group(P<0.05).Conclusion The combination of Shensong Yangxin Capsules and trazodone improves sleep quality in patients with chronic insomnia following percutaneous coronary intervention for stable angina pectoris.It enhances polysomnography parameters,reduces inflammatory responses and myocardial damage,and lowers the risk of cardiovascular adverse events.关键词
稳定型心绞痛/慢性失眠/经皮冠状动脉介入治疗/参松养心胶囊/曲唑酮/临床疗效Key words
stable angina pectoris/chronic insomnia/percutaneous coronary intervention/Shensong Yangxin Capsules/trazodone/clinical efficacy分类
医药卫生引用本文复制引用
吴丹,曲萌..参松养心胶囊联合曲唑酮治疗稳定型心绞痛PCI术后慢性失眠患者的临床疗效研究[J].中国现代医学杂志,2026,36(4):91-96,6.基金项目
陕西省重点研发计划(No:2022SF-1071) （No:2022SF-1071）
