中国实用儿科杂志2026，Vol.41Issue(1)：30-36,7.DOI:10.19538/j.ek2026010607
中、重度缺氧缺血性脑病患儿亚低温神经保护策略及远期评价
Neuroprotection strategies and long-term evaluation of therapeutic hypothermia for neonates with moderate to severe hypoxic-ischemic encephalopathy
摘要
Abstract
Therapeutic hypothermia is the standard treatment strategy for moderate to severe hypoxic-ischemic encephalopathy(HIE).It exerts significant neuroprotective effects through multiple mechanisms,including decreasing brain tissue metabolic levels,suppressing neuroinflammation,reducing brain tissue cell apoptosis,improving blood-brain barrier permeability,and reducing the production of free radicals,etc.Currently,therapeutic hypothermia alone is insufficient in neuroprotection strategies for infants with moderate to severe HIE.It is crucial to explore combined neuroprotection strategies of hypothermia along with erythropoietin,antiepileptic drugs,melatonin,and stem cell transplantation for the treatment of moderate to severe HIE.Furthermore,hypothermia therapy can significantly reduce long-term mortality and incidence of neurological adverse events in individuals with moderate to severe HIE.However,the long-term evaluation of hypothermia for neonates beyond 6 hours after birth or preterm infants under 35 weeks of gestation warrants further investigation,which may provide scientific reference for the clinical treatment of moderate to severe HIE.关键词
中、重度缺氧缺血性脑病/亚低温治疗/神经保护/远期疗效Key words
moderate to severe hypoxic-ischemic encephalopathy/therapeutic hypothermia/neuroprotection/long-term effect分类
医药卫生引用本文复制引用
邱霞,唐军..中、重度缺氧缺血性脑病患儿亚低温神经保护策略及远期评价[J].中国实用儿科杂志,2026,41(1):30-36,7.基金项目
国家重点研发计划(2024YFC2707705) （2024YFC2707705）
四川省自然科学基金项目(2025ZNSFSC0639、2025ZNSFSC1675) （2025ZNSFSC0639、2025ZNSFSC1675）
吴阶平医学基金会临床科研专项资助基金(320.6750.2025-9-27) （320.6750.2025-9-27）
