中国实用儿科杂志2026，Vol.41Issue(1)：50-55,6.DOI:10.19538/j.ek2026010611
纯母乳喂养过敏婴儿母亲乳汁游离氨基酸含量分析及意义
Analysis of free amino acids content in breast milk of mothers with allergic infants under exclusive breastfeeding and its significance
摘要
Abstract
Objective To determine the content of free amino acids(FAAs)in breast milk from mothers of infants with allergies who are exclusively breastfed,analyze the differences in FAA distribution characteristics between these mothers and those of non-allergic infants exclusively breastfed,and explore the mechanism of food allergy in the allergic infants and its significance in the optimization of breastfeeding strategies.Methods Exclusively breastfed infants aged 0.5-6.0 months were selected,who visited the Outpatient Department of Pediatrics and the Department of Preventive Health Care of the First Affiliated Hospital of Kunming Medical University from September 2022 to May 2023.The infants were paired and divided into a non-allergic group(n=30)and an allergic group(n=30)based on the presence or absence of allergic manifestations.Breast milk samples were collected from the mothers of these infants.Tandem mass spectrometry(LC-MS/MS)was used for quantitative detection of FAAs in the breast milk samples.The differences in the contents of FAA between the two groups were analyzed and compared,and their statistical significance was explored.Results The total amino acid content in the non-allergic group was higher than that in the allergic group.The contents of leucine(t=2.336,P=0.023)and ornithine(t=-2.93,P=0.005)showed statistically significant differences between the two groups(P＜0.05),while no statistically significant differences were observed in the contents of other amino acids between the two groups(P＞0.05).Specifically,the leucine content in the non-allergic group was higher than that in the allergic group,and the ornithine content was lower in the non-allergic group than in the allergic group.Conclusion In this study,the total amino acid content in the allergic group is lower than that in the non-allergic group,suggesting that the degree of protein degradation in breast milk of the allergic group may be lower,which may be associated with the mechanism of allergy development in exclusively breastfed infants.The higher leucine level in the non-allergic group may affect the infant's immune regulation and intestinal barrier function,thereby reducing the risk of allergies.关键词
母乳喂养/游离氨基酸/亮氨酸/食物过敏/免疫调节Key words
breastfeeding/free amino acids/leucine/food allergy/immunoregulation分类
医药卫生引用本文复制引用
李湛华,黄永坤,段江,王琼,谢振荣,李碧桃,李檬,熊晶晶,谢昀霏,熊朝霞..纯母乳喂养过敏婴儿母亲乳汁游离氨基酸含量分析及意义[J].中国实用儿科杂志,2026,41(1):50-55,6.基金项目
国家自然科学基金项目(81960102) （81960102）
