中国药科大学学报2026，Vol.57Issue(1)：11-18,8.DOI:10.11665/j.issn.1000-5048.2025072102
2020-2024年:解锁"老药新用"新趋势与新策略
New trends and new strategies of drug repurposing:2020-2024
摘要
Abstract
The research and development of innovative drug have progressed remarkably,but the long development circle and high failure rate have become the bottleneck.Drug repurposing,discovering new indications of approved drugs,is a strategy to overcome these obstacles.By exploring new indications for approved drugs,rapid progress has been made in basic research and clinical translation in recent years.Rich resources of drugs,proven security,efficient development workflow and reduced cost are core advantages of this strategy,making the strategy a crucial direction of optimizing the pipeline of drug research and development.This review systematically summarizes drug repurposing cases that have received clinical approval over the past five years,and proposes core strategies for drug repurposing,including approaches based on targets,pathways,drug similarity,post-treatment phenotypes,and clinical side effects,aiming to provide some strategic guidance for drug repurposing efforts.关键词
老药新用/药物研发策略/新适应证/研究进展Key words
drug repurposing/drug development strategies/new indications/research progress分类
医药卫生引用本文复制引用
陈方溯,杨俊杰,杜佳玉,黄诗淼,张宇轩,尤启冬,王磊,张秋月..2020-2024年:解锁"老药新用"新趋势与新策略[J].中国药科大学学报,2026,57(1):11-18,8.基金项目
This study was supported by the National Natural Science Foundation of China(No.82173741,No.82304309) （No.82173741,No.82304309）
the Natural Science Foundation of Jiangsu Province(BK20231014) （BK20231014）
and the National Innovation and Entrepreneurship Training Program for Undergraduate(No.202510316017) 国家自然科学基金项目(No.82173741,No.82304309) （No.202510316017）
江苏省自然科学基金项目(BK20231014) （BK20231014）
国家级大学生创新创业训练计划项目(No.202510316017) （No.202510316017）
