中国药科大学学报2026，Vol.57Issue(1)：28-33,6.DOI:10.11665/j.issn.1000-5048.2025031901
疟原虫组蛋白去乙酰化酶抑制剂研究进展
Research progress of Plasmodium falciparum histone deacetylase inhibitors
摘要
Abstract
Histone deacetylase has proved to be a promising new antimalarial target in the development of novel antimalarial drugs.This article introduces the mechanism of action of histone deacetylase inhibitors and their antimalarial activity,with a focus on the discovery process of Plasmodium histone deacetylase inhibitors and their recent research progress both domestically and internationally.Recent research findings on hydroxamic acid-based and cyclic peptide inhibitors are reviewed and analyzed in detail according to their different structural types.Key challenges hindering drug development and approval,such as drug toxicity issues and the lag in related biological studies,are highlighted.Furthermore,future directions for drug research and development are proposed,offering insights for the further development of new antimalarial drugs.关键词
疟疾/恶性疟原虫/组蛋白去乙酰化酶/抑制剂Key words
malaria/Plasmodium falciparum/histone deacetylase/inhibitor分类
医药卫生引用本文复制引用
赵磊,张梦蝶,孙鹏..疟原虫组蛋白去乙酰化酶抑制剂研究进展[J].中国药科大学学报,2026,57(1):28-33,6.基金项目
This study was supported by the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ13-YQ-098) 中央公益性科研院所基本科研业务费项目(ZZ13-YQ-098) （ZZ13-YQ-098）
