中国中医基础医学杂志2026，Vol.32Issue(2)：263-267,5.
系统生物学在气虚血瘀证候研究中的应用
Application of Systems Biology in the Study of Qi Deficiency and Blood Stasis Syndrome
摘要
Abstract
Qi deficiency and blood stasis syndrome(QDBS)is the core syndrome of clinical differentiation and research in traditional Chinese medicine.With the continuous advancement of modernization of traditional Chinese medicine,revealing the essence of this syndrome has become a key issue now.The core pathogenesis of this syndrome is the deficiency of vital energy leading to poor blood circulation and stagnation in the body,with complex and diverse clinical manifestations.However,the traditional four diagnostic methods of"observation,auscultation and olfaction inquiry,and pulse palpation"in traditional Chinese medicine lack exclusive objective indicators,which hinders the accurate diagnosis and efficacy evaluation of QDBS.Multi-omics technologies(genomics,transcriptomics,proteomics,metabolomics,etc.)have the characteristic of dynamically studying organisms from a holistic perspective,which is highly compatible with the connotation of the"holistic view"of traditional Chinese medicine syndrome,providing a powerful tool for systematically analyzing QDBS from multiple levels and perspectives.This review aims to summarize the research progress of systems biology techniques in revealing the formation and development mechanisms of QDBS in recent years,further optimize relevant research methods,deepen the understanding of syndrome mechanisms,and provide new ideas for the treatment of QDBS.关键词
气虚血瘀证/多组学技术/基因组学/转录组学/蛋白质组学/代谢组学/证候研究Key words
Qi deficiency and blood stasis syndrome/Multi-omics technologies/Genomics/Transcriptomics/Proteomics/Metabolomics/Syndrome research分类
医药卫生引用本文复制引用
钟舒静,孙明谦,苗兰,李瑛,林力..系统生物学在气虚血瘀证候研究中的应用[J].中国中医基础医学杂志,2026,32(2):263-267,5.基金项目
国家重点研发计划"中医药现代化研究"重点专项(2023YFC3503605) （2023YFC3503605）
中国中医科学院优秀青年科技人才培养专项(ZZ17-YQ-003) （ZZ17-YQ-003）
