中国医院用药评价与分析2026，Vol.26Issue(1)：25-28,34,5.DOI:10.14009/j.issn.1672-2124.2026.01.004
国家专利中药复方治疗胃食管反流病的用药规律分析
Medication Rules of National-Patented Traditional Chinese Medicine Compound Formulas in the Treatment of Gastroesophageal Reflux Disease
摘要
Abstract
OBJECTIVE:To explore the medication rules of national-patented traditional Chinese medicine compound formulas in the treatment of gastroesophageal reflux disease(GERD).METHODS:Patents were retrieved from the China National Intellectual Property Administration Patent Publication Announcement Website(the search time was from the establishment of the database to Sept.10th,2025),Excel was used to construct database and R(4.1.1)software was used to conduct data analysis.RESULTS:A total of 227 national-patented traditional Chinese medicine formulas were enrolled,involving 461 traditional Chinese medicines,with high-frequency herbs such as licorice,Aurantii fructus immaturus and Rhizoma pinelliae,with the properties were mainly warm,cold and neutral,the flavors were mainly pungent,bitter and sweet,the meridian tropisms concentrated on liver,stomach,lung and spleen,the function classifications were mainly deficiency-tonifying,Qi-regulating,phlegm-resolving,cough-relieving and asthma-alleviating.The core drug pairs and auxiliary traditional Chinese medicine were highly identical with classical formulas such as peony-licorice decoction,Zuojin pills and Sini powder.Four categories of novel prescription were obtained from cluster analysis.One core prescription(Radix bupleuri,Aurantii fructus immaturus,Radix paeoniae alba,licorice,Rhizoma coptidis,Rhizoma pinelliae and Pericarpium citri reticulatae)and synergistic combinations for concomitant syndromes were obtained from complex network analysis.CONCLUSIONS:National-patented traditional Chinese medicine compound formulas in the treatment of GERD is primarily focus on spleen-strengthening and liver-smoothing,phlegm-resolving and heat-clearing,liver-stomach harmonizing,treatment strategies including heat-clearing,acid-suppressing,stasis-resolving and spleen-strengthening are tailored to patients'disease stages and syndrome presentations.关键词
胃食管反流病/数据挖掘/复方专利/中药/用药规律Key words
Gastroesophageal reflux disease/Data mining/Compound patents/Traditional Chinese medicine/Medication rules分类
医药卫生引用本文复制引用
张远红,赵婉竹,蔡瑞,黄圣意,任涵,黄金玲..国家专利中药复方治疗胃食管反流病的用药规律分析[J].中国医院用药评价与分析,2026,26(1):25-28,34,5.基金项目
国家自然科学基金面上项目(No.81573864) （No.81573864）
