中国药业2026，Vol.35Issue(4)：86-91,6.DOI:10.3969/j.issn.1006-4931.2026.04.015
盐酸羟考酮超前镇痛用于结直肠癌大鼠术后效果评价
Evaluation of Preemptive Analgesia with Oxycodone Hydrochloride on Postoperative Effects in Rats with Colorectal Cancer
摘要
Abstract
Objective To investigate the effect of preemptive analgesia with oxycodone hydrochloride on postoperative effects in rats with colorectal cancer.Methods A total of 72 SD rats were subcutaneous injected with 1,2-dimethylhydrazine(DMH)30 mg/kg in the cervico-dorsal region,once a week for 18 consecutive weeks to replicate rats with colorectal cancer models.After successful modeling,the rats were continuously fed for 16 weeks and then randomly divided into the model group(0.2 mg/kg normal saline,30 min before operation),the preemptive analgesia group(2 mg/kg,30 min before operation)and the postoperative analgesia group(2 mg/kg,30 min after operation),with oxycodone hydrochloride or equal volume of normal saline were injected intraperitoneally.Another 18 SD rats were selected as the control group(0.2 mg/kg normal saline,30 min before operation).Mechanical stimulation and thermal radiation were used to detect the paw withdrawal mechanical threshold(PWT)and paw withdrawal thermal latency(PWL)of rats on the day before operation(D0),the first day after operation(D1),and the second day after operation(D2).Enzyme-linked immunosorbent assay(ELISA)method was used to detect the serum levels of nitric oxide(NO),substance P,cortisol(Cor),epinephrine(E)and norepinephrine(NE),interleukin(IL)-17 and IL-22 in peripheral blood in rats.Flow cytometry method was used to detect the proportion of helper T cells(Th)17 and Th22.Results Compared with the model group,at D1 and D2,PWT and PWL in the preemptive analgesia group and the postoperative analgesia group were significantly increased(P<0.05),the level of NO,substance P,Cor,E,NE,IL-17,IL-22,the proportion of Th17 cells and Th22 cells in the preemptive analgesia group were significantly decreased(P<0.05),and the change amplitude of all the above indicators in the preemptive analgesia group were significantly greater than those in the postoperative analgesia group(P<0.05).Conclusion Preemptive analgesia with oxycodone hydrochloride can reduce postoperative pain,inhibit systemic stress response,and improve cellular immune function by regulating the proportion of Th17 and Th22 cells in rats with colorectal cancer.关键词
盐酸羟考酮/超前镇痛/结直肠癌/免疫功能Key words
oxycodone hydrochloride/preemptive analgesia/colorectal cancer/immune function分类
医药卫生引用本文复制引用
刘卓,张树波,贺子蕗,刘守友,杨立群..盐酸羟考酮超前镇痛用于结直肠癌大鼠术后效果评价[J].中国药业,2026,35(4):86-91,6.基金项目
河北省医学科学研究课题研究项目[20211806]. （）
