中国医院用药评价与分析2026，Vol.26Issue(1)：60-63,4.DOI:10.14009/j.issn.1672-2124.2026.01.012
复方苦参注射液治疗老年子宫内膜癌化疗后癌因性疲乏的疗效观察
Efficacy of Compound Kushen Injection in the Treatment of Cancer-Related Fatigue in Elderly Patients with Endometrial Cancer After Chemotherapy
摘要
Abstract
OBJECTIVE:To probe into the effects of compound Kushen injection on cancer-related fatigue and life quality in elderly patients with advanced endometrial cancer after chemotherapy.METHODS:A total of 98 elderly advanced endometrial cancer patients with cancer-related fatigue after chemotherapy admitted into Oncology Department,Obstetrics and Gynecology Department in Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology from Jan.1st,2022 to Jan.1st,2025 were selected,patients were divided into observation group(49 cases)and control group(49 cases)according to different therapeutic methods.The control group was given TP regimen(paclitaxel+cisplatin)or TC regimen(paclitaxel+carboplatin)for chemotherapy,while the observation group received compound Kushen injection combined with TP or TC regimens for chemotherapy,both groups were treated for 2 courses,with each course for 21 d.The efficacy of cancer-related fatigue,life quality,the incidence of adverse drug reactions after treatment,and changes of serum C-reactive protein before and after treatment were compared between two groups.RESULTS:After treatment,the effective rate for cancer-related fatigue of observation group was 51.02%(25/49),significantly higher than 14.29%(7/49)of control group;the improvement rate of life quality of observation group was 61.22%(30/49),significantly higher than 36.73%(18/49)of control group,with statistically significant differences(P＜0.05).After treatment,the serum C-reactive protein level of observation group was significantly lower than that of control group,with statistically significant difference(P＜0.05).The incidence of adverse drug reactions of observation group was 24.49%(12/49),significantly lower than 44.90%(22/49)of control group,with statistically significant differences(P＜0.05).CONCLUSIONS:For elderly patients with advanced endometrial cancer,compound Kushen injection can effectively improve cancer-related fatigue after chemotherapy,reduce adverse drug reactions and improve life quality.关键词
复方苦参注射液/老年/子宫内膜癌患者/癌因性疲乏Key words
Compound Kushen injection/Elderly patients/Patients with endometrial cancer/Cancer-related fatigue分类
医药卫生引用本文复制引用
马瑞,余舒扬,马倩,申利..复方苦参注射液治疗老年子宫内膜癌化疗后癌因性疲乏的疗效观察[J].中国医院用药评价与分析,2026,26(1):60-63,4.基金项目
湖北省卫生健康委科研项目(面上项目)(No.WJ2023M044) （面上项目）
