中国药理学通报2026，Vol.42Issue(2)：201-206,6.DOI:10.12360/CPB202507125
迁移体在疾病中的研究进展
Research advances on migrasomes in diseases
摘要
Abstract
Migrasomes are newly discovered organelles defined as tetraspanin-enriched vesicular structures produced by migrat-ing cells.Although morphologically similar to vesicles,migra-somes are distinct from other extracellular vesicles,such as exo-somes,in their biogenesis mechanisms and functions,and are ultimately released into the extracellular space.The formation of migrasomes primarily depends on the breakage of retraction fi-bers during cell migration.These structures are enriched with various signaling molecules,proteins,and RNA,enabling them to play crucial roles in intercellular communication,devel-opmental regulation,and disease processes.Given these criti-cal functions,migrasomes have emerged as a potential novel tar-get for understanding fundamental biological processes and de-veloping clinical therapies.However,despite preliminary prog-ress in understanding their biogenesis and functions,the spe-cific mechanisms of action in the pathogenesis of related dis-eases,as well as the potential value of migrasomes as diagnostic biomarkers or therapeutic targets,still require in-depth explora-tion and systematic elucidation.Therefore,this review aims to summarize the latest advances in migrasome research within dis-ease contexts,provide a systematic overview of their roles in pathogenesis,and establish a theoretical foundation for their po-tential application as diagnostic biomarkers and therapeutic tar-gets.关键词
迁移体/细胞外囊泡/信号传递/细胞间通讯/线粒体胞吐/收缩纤维Key words
migrasomes/extracellular vesicles/signal trans-duction/intercellular communication/mitocytosis/retraction fi-bers分类
医药卫生引用本文复制引用
陈智涵,王晨曦,蒋丽萍..迁移体在疾病中的研究进展[J].中国药理学通报,2026,42(2):201-206,6.基金项目
国家自然科学基金资助项目(No 82460719) （No 82460719）
