中国医院用药评价与分析2026，Vol.26Issue(1)：67-75,9.DOI:10.14009/j.issn.1672-2124.2026.01.014
环泊酚用于全身麻醉或镇静患者的疗效及安全性的系统评价再评价
Overview of Systematic Evaluation on Efficacy and Safety of Ciprofol for General Anesthesia or Sedation:Re-Assessment of Systematic Review
摘要
Abstract
OBJECTIVE:To summarize and evaluate the existing systematic reviews/Meta-analyses(SR/MA)evidence for comparison of ciprofol and propofol through the re-assessment of systematic review methods,so as to provide evidence-based guidance for clinical medication.METHODS:English and Chinese databases such as PubMed,Embase,the Cochrane Library,and CNKI were systematically searched to identify relevant SR/MA of comparison of ciprofol and propofol for general anesthesia or sedation(with a search period from database establishment to Nov.30th,2024).Methodological quality was assessed by using A Measurement Tool to Assess Systematic Reviews(AMSTAR 2),evidence certainty was graded via the Grading of Recommendations Assessment,Development and Evaluation(GRADE)tool.Overlap of primary studies was calculated,and core outcome measures were summarized.RESULTS:Fifteen SR/MA were included.Methodological quality assessment of AMSTAR 2 revealed 3 high-quality literature,while most literature had critical flaws.GRADE evaluation indicated low or very low certainty for most efficacy and safety evidence.Overlap analysis demonstrated high redundancy among primary studies(correct overlapping areas=0.17).Results showed comparable efficacy between ciprofol and propofol in sedation success rates,with ciprofol exhibiting advantages in reducing injection pain,improving patient satisfaction,and enhancing respiratory safety,partial indicators had relatively high evidence quality.Inconsistent findings were observed in hemodynamic events and intraoperative movement control,lacking robust evidence.CONCLUSIONS:Current evidence suggests that ciprofol offers superior safety in specific aspects compared with propofol while maintaining equivalent efficacy for patients undergoing general anesthesia or sedation.However,the overall low quality of included studies and regional concentration limit the generalizability of findings.High-quality primary research and SR are warranted to enhance evidence reliability and clinical applicability.关键词
环泊酚/丙泊酚/麻醉/镇静/系统评价再评价/重叠分析Key words
Ciprofol/Propofol/Anesthesia/Sedation/Re-assessment of systematic review/Overlap analysis分类
医药卫生引用本文复制引用
王之舟,董宪喆,邢晓璇,王可,花一鸣,张晓彤,冯英楠,李晓曦,伍超,张兰..环泊酚用于全身麻醉或镇静患者的疗效及安全性的系统评价再评价[J].中国医院用药评价与分析,2026,26(1):67-75,9.基金项目
国家卫生健康委医院管理研究医疗质量(循证)管理研究项目(No.YLZLXZ24K010) （循证）
北京市卫生健康委员会委托项目(No.药械处2025年度+11) （No.药械处2025年度+11）
