中国药理学通报2026，Vol.42Issue(2)：207-216,10.DOI:10.12360/CPB202505110
从分子到临床:抑郁症异质性的中西医多维解析与个体化治疗策略研究进展
From molecular to clinical:research progress of multidimensional analysis and individualized treatment strategies of Chinese and Western medicine for heterogeneity of depression
摘要
Abstract
Due to the differences in individual constitution and living environment of patients with depression,they are often accompanied with various complications,so there are signifi-cant differences in clinical manifestations and drug efficacy evaluation.Commonly used antidepressants are prone to cause serious adverse reactions,including cerebral hemorrhage,erec-tile dysfunction,withdrawal reaction,suicidal ideation,and in-creased behavioral risk.Based on the theories of traditional Chi-nese and Western medicines,this review comprehensively ana-lyzes and summarizes the different types of depression and indi-vidual differences after administration,discusses in depth its different pathogenesis,and emphasizes the indispensability of studying the heterogeneity of depression for individualized treat-ment of patients.In addition,this paper also summarizes the strategies of Chinese and Western medicines in different stages of depression,providing guidance for scientific and detailed evaluation of patients,the treatments of different symptoms,the theoretical basis for the in-depth and comprehensive interpreta-tion of the mechanism of depression,and the future directions for the clinical treatment of depression with the combined appli-cations of traditional Chinese medicines and Western medi-cines.关键词
抑郁症/异质性/不良反应/同病异治/辨证论治/中西药联用Key words
depression/heterogeneity/adverse drug reactions/treatment of the same disease with different therapeutic methods/treatment based on pattern differentiation/combined applications of traditional Chinese medicines and Western medicines分类
医药卫生引用本文复制引用
田佳雪,秦雪梅,刘晓节..从分子到临床:抑郁症异质性的中西医多维解析与个体化治疗策略研究进展[J].中国药理学通报,2026,42(2):207-216,10.基金项目
国家自然科学基金资助项目(No 82274360) （No 82274360）
经方扶阳山西省重点实验室开放课题研究基金资助项目(No CPSY202501) （No CPSY202501）
山西省中医药管理局资助项目(No 2024ZYY2A032) （No 2024ZYY2A032）
