中国药理学通报2026，Vol.42Issue(2)：225-229,5.DOI:10.12360/CPB202506090
毒品成瘾相关神经环路的研究进展
Research progress on neural circuits related to drug addiction
摘要
Abstract
Drug addiction represents a complex chronic brain disorder,characterized by its inherent addictiveness and high relapse rate.As complex functional networks constructed by neurons through synaptic connections,neural circuits have been progressively elucidated by recent studies to play critical regulatory roles in the formation,maintenance and relapse of drug addiction,emerging as the core entry point for current re-search on the neural mechanisms of addiction.The neural cir-cuits primarily involved in addiction include the mesolimbic ventral tegmental area-nucleus accumbens(VTA-NAc)reward circuit,prefrontal cortex(PFC)-associated executive control circuits,and paraventricular thalamic nucleus(PVT)-related circuits.Neural circuits can also mediate the formation of addic-tive memories through the synergistic integration of drug reward effects and environmental cues.Studies have shown that spe-cific interventions targeting neural circuits can effectively extin-guish addictive memories and alleviate relapse.This study sys-tematically reviews the recent research advances,summarizing the key neural circuits of drug addiction and their roles in addic-tive mechanisms,with the aim of providing theoretical support for the development of precision therapeutic strategies based on neural circuit intervention.Future research needs to further re-veal the dynamic changes in neural circuits,explore the cellular and molecular mechanisms of different types of addiction,and promote the development of targeted interventions for neural cir-cuits.关键词
毒品成瘾/神经环路/成瘾机制/奖赏环路/记忆环路/伏隔核/腹侧被盖区Key words
drug addiction/neural circuits/addictive mecha-nisms/reward circuits/memory circuits/nucleus accumbens/ventral tegmental area分类
医药卫生引用本文复制引用
田云青,饶梦洁,陶慧姗,王婵,刘柳,曾晓锋..毒品成瘾相关神经环路的研究进展[J].中国药理学通报,2026,42(2):225-229,5.基金项目
国家自然科学基金资助项目(No 82360336) （No 82360336）
云南省基础研究计划重点项目(No 202401AS070059) （No 202401AS070059）
国家卫健委毒品依赖和戒治重点实验室开放课题(No KN202401) （No KN202401）
昆明医科大学研究生教育创新基金项目(No 2025S016) （No 2025S016）
昆明医科大学法医毒物学一流学科团队(No 2024XKTDYS10) （No 2024XKTDYS10）
