中国现代医学杂志2026，Vol.36Issue(3)：20-25,6.DOI:10.3969/j.issn.1005-8982.2026.03.004
外周血炎症因子水平在重症肺炎支原体肺炎合并胸腔积液患儿临床转归中的意义
Changes in peripheral blood inflammatory cytokines and their relationship with clinical outcomes in children with severe mycoplasmal pneumoniae pneumonia complicated by pleural effusion
摘要
Abstract
Objective To investigate the changes in peripheral blood inflammatory factors in children with severe mycoplasmal pneumoniae pneumonia(SMPP)complicated by pleural effusion and their relationship with clinical outcomes.Methods A retrospective study was conducted,in which 200 children with SMPP complicated by pleural effusion who were admitted to Nanchong Central Hospital from February 2020 to December 2023 were enrolled as the observation group.Additionally,50 children with SMPP without pleural effusion admitted during the same period were selected as the control group.The levels of interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),and soluble interleukin-2 receptor(sIL-2R)were compared between the two groups.Moreover,the levels of inflammatory factors were analyzed among children in the observation group with different treatment responses and clinical outcomes,and the relationship between inflammatory levels and clinical outcomes was explored.Results The levels of IL-6,IL-8,PCT,CRP,TNF-α,and sIL-2R in the observation group were significantly higher than those in the control group(all P<0.05).Seven days after treatment,the peripheral blood levels of IL-6,PCT,CRP,IL-8,TNF-α,and sIL-2R in the ineffective treatment group were significantly higher than those in the effective treatment group(all P<0.05).At discharge,the peripheral blood levels of IL-6,PCT,CRP,IL-8,TNF-α,and sIL-2R in the non-recovery group were significantly higher than those in the recovery group(all P<0.05).Multivariate binary logistic regression analysis showed that high levels of sIL-2R[(O^R)=7.608(95%CI:1.418,40.820)],IL-6[(O^R)=1.591(95%CI:1.294,1.958)],IL-8[(O^R)=1.240(95%CI:1.072,1.434)],and PCT[(O^R)=3.555(95%CI:1.174,10.763)]were independent risk factors for ineffective treatment response in children(all P<0.05);while high levels of PCT[(O^R)=3.397(95%CI:1.069,10.793)],IL-6[(O^R)=1.601(95%CI:1.279,2.003)],IL-8[(O^R)=1.216(95%CI:1.038,1.424)],and TNF-α[(O^R)=1.236(95%CI:1.060,1.441)]were independent risk factors for non-recovery as the clinical outcome in children(all P<0.05).Conclusion The peripheral blood inflammatory cytokine levels in children with SMPP complicated by pleural effusion are closely related to clinical outcomes.Monitoring the levels of IL-6,IL-8,PCT,and TNF-α can provide important information for assessing treatment effectiveness and short-term clinical outcomes,thereby aiding in the adjustment and optimization of clinical treatment strategies.关键词
肺炎支原体肺炎/胸腔积液/炎症因子/治疗反应/临床结局Key words
mycoplasmal pneumoniae pneumonia/pleural effusion/inflammatory cytokines/treatment response/clinical outcomes分类
医药卫生引用本文复制引用
张娟,唐炜,刘娟,孙益,王力夫..外周血炎症因子水平在重症肺炎支原体肺炎合并胸腔积液患儿临床转归中的意义[J].中国现代医学杂志,2026,36(3):20-25,6.基金项目
陕西省自然科学基础研究计划项目(No:2022JM-534) （No:2022JM-534）
