中国药房2026，Vol.37Issue(3)：395-400,6.DOI:10.6039/j.issn.1001-0408.2026.03.21
人脐带间充质干细胞干预神经退行性变性疾病的研究进展
Research progress on the intervention of human umbilical cord mesenchymal stem cell in neurodegenerative disease
摘要
Abstract
Human umbilical cord mesenchymal stem cell(hUC-MSC)as a cell-based therapeutic strategy have demonstrated significant application potential in the field of intervention for neurodegenerative disease(NDD)due to their advantages such as self-renewal,multi-directional differentiation,and low immunogenicity.hUC-MSC effectively intervenes in the pathological features and neurological functions of various disease models such as Alzheimer disease,Parkinson's disease,amyotrophic lateral sclerosis,and multiple sclerosis primarily through multiple mechanisms such as homing and differentiation,mediating paracrine actions and releasing exosomes,as well as immune regulation and anti-inflammation.Some clinical studies have also preliminarily verified their safety and effectiveness.Currently,its research still faces challenges such as immune rejection reactions requiring further observation,long-term safety needing evaluation,mechanisms of action not being fully elucidated,and slow progress in clinical trials.Future research needs to establish pharmaceutical standards for hUC-MSC,deepen their pharmacological mechanisms and clinical trials,ultimately providing new and effective drug treatment options for patients with NDD.关键词
人脐带间充质干细胞/神经退行性变性疾病/阿尔茨海默病/帕金森病/肌萎缩侧索硬化症/多发性硬化/归巢/外泌体Key words
human umbilical cord mesenchymal stem cell/neurodegenerative disease/Alzheimer disease/Parkinson's disease/amyotrophic lateral sclerosis/multiple sclerosis/homing/exosome分类
医药卫生引用本文复制引用
徐红彩,许玉珉,刘诗雨,闫化雨,刘源,杨鑫,吴亚博..人脐带间充质干细胞干预神经退行性变性疾病的研究进展[J].中国药房,2026,37(3):395-400,6.基金项目
国家科技重大专项课题(No.2024ZD0522202) （No.2024ZD0522202）
河南省博士后基金项目(No.HN2022083) （No.HN2022083）
河南省医学科技攻关计划省部共建重点项目(No.SBGJ202302101) （No.SBGJ202302101）
河南省科技发展计划项目(No.242102311255) （No.242102311255）
河南省卫生健康委国家中医药传承创新中心科研专项(No.2023ZXZX1004) （No.2023ZXZX1004）
