中国现代医学杂志2026，Vol.36Issue(3)：72-76,5.DOI:10.3969/j.issn.1005-8982.2026.03.011
瑞马唑仑联合曲马多在上消化道内镜黏膜下剥离术中的应用研究
Study of remimazolam combined with tramadol in endoscopic submucosal dissection of upper gastrointestinal tract
摘要
Abstract
Objective To explore the clinical application effect of remimazolam combined with tramadol in endoscopic submucosal dissection(ESD)of upper gastrointestinal tract.Methods 100 patients who underwent ESD from January 2024 to August 2025 were selected and randomly divided into the observation group(remimazolam+tramadol)and the control group(remimazolam+sufentanil)by random number table method,with 50 cases in each group.Postoperative VAS score,BIS value range maintenance rate,extubation time,adverse reactions and overall clinical outcomes were compared between the two groups.Results The rate of low VAS scores in patients of the observation group at 3 h,6 h,12 h and 24 h postoperatively was higher than that in the control group(P<0.05);The proportion of time that bispectral index(BIS)values stayed within the range of 45-60 in the observation group was higher than that in the control group(P<0.05);The postoperative extubation time of patients in the observation group was shorter than that in the control group(P<0.05);The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05);The excellent and good rate in the observation group was higher than that in the control group(P<0.05).Conclusion Remimazolam combined with tramadol can achieve better analgesia and sedation,shorten the recovery time,and reduce the adverse reactions in ESD of upper gastrointestinal tract,which has good clinical application value.关键词
内镜黏膜下剥离术/瑞马唑仑/曲马多/应用效果Key words
endoscopic submucosal dissection/remimazolam/tramadol/application effects分类
医药卫生引用本文复制引用
孙鑫,宋杰,杨雪峰,葛建林,刘增慧,苏倩,钟超超..瑞马唑仑联合曲马多在上消化道内镜黏膜下剥离术中的应用研究[J].中国现代医学杂志,2026,36(3):72-76,5.基金项目
江苏省卫生健康委科研项目(No:MQ2024051) （No:MQ2024051）
南通市第一人民医院高层次科技项目培育基金(No:YPYJJYB24008) （No:YPYJJYB24008）
