中国中药杂志2026，Vol.51Issue(3)：880-889,10.DOI:10.19540/j.cnki.cjcmm.20251103.501
十味龙胆花颗粒/胶囊治疗支气管炎有效性与安全性的系统评价与Meta分析
Shiwei Longdanhua Granules/Capsules for treatment of bronchitis:systematic review and Meta-analysis on efficacy and safety
摘要
Abstract
This study aimed to systematically evaluate the clinical efficacy and safety of Shiwei Longdanhua Granules/Capsules in the treatment of bronchitis,providing evidence-based support for clinical practice.Databases including CNKI,Wanfang,VIP,SinoMed,PubMed,EMbase,Cochrane Library,and Web of Science were searched for randomized controlled trials(RCTs)of Shiwei Longdanhua Granules/Capsules for bronchitis,from database inception to July 2025.Two investigators independently extracted data from the included studies,including sample size,patient characteristics,interventions,outcome measures,and adverse effects.Methodological quality was assessed using appropriate quality assessment tools,and Meta-analysis was performed using RevMan 5.4 software.A total of 16 RCTs involving 2 068 patients with bronchitis were included.Meta-analysis showed that,compared with antibiotics combined with expectorants and cough suppressants,Shiwei Longdanhua Granules improved the total efficiency(RR=1.33,95%CI[1.17,1.51])and efficiency of relieving coughing(RR=1.23,95%CI[1.11,1.36]).Compared with antibiotics alone,Shiwei Longdanhua Granules improved the total efficiency(RR=1.25,95%CI[1.16,1.35])and shortened the time to improvement of pulmonary rales(MD=-1.44,95%CI[-1.82,-1.07]),fever(MD=-1.08,95%CI[-1.18,-0.98]),and coughing(MD=-1.46,95%CI[-1.84,-1.09]).Combined with antibiotics,Shiwei Longdanhua Granules/Capsules further reduced the time to cough relief(MD=-1.13,95%CI[-1.54,-0.71])and fever(MD=-1.14,95%CI[-1.31,-0.97]).For acute bronchitis in children,Shiwei Longdanhua Granules/Capsules improved the total efficiency(RR=1.29,95%CI[1.09,1.52])and efficiency of relieving coughing(RR=1.35,95%CI[1.05,1.75])compared with antibiotics alone.These results suggest that Shiwei Longdanhua Granules/Capsules may have therapeutic effects for acute bronchitis,acute exacerbations of chronic bronchitis,and acute bronchitis in children.However,the number of clinical studies is limited,and their quality requires further improvement.Standardization of clinical trial procedures is needed to enhance evidence quality and provide stronger support for clinical application.关键词
十味龙胆花颗粒/胶囊/支气管炎/随机对照试验/系统评价Key words
Shiwei Longdanhua Granules/Capsules/bronchitis/randomized controlled trial/systematic review引用本文复制引用
张居文,刘娟,于凡雅,余俊鸿,王阿伟,余昊宇,陈薇..十味龙胆花颗粒/胶囊治疗支气管炎有效性与安全性的系统评价与Meta分析[J].中国中药杂志,2026,51(3):880-889,10.基金项目
北京中医药大学教育科学研究课题(XBB23028) （XBB23028）
北京中医药大学横向科研发展基金项目(2025-HXFZJJ-008) （2025-HXFZJJ-008）
