中国肿瘤外科杂志2026，Vol.18Issue(1)：96-104,9.DOI:10.3969/j.issn.1674-4136.2026.01.015
调控肿瘤微环境以克服乳腺癌免疫治疗的耐药
Modulating the tumor microenvironment to overcome immunotherapy resistance in breast cancer
摘要
Abstract
While immune checkpoint inhibitors have shown substantial clinical benefits in treating breast cancer,their overall efficacy is limited by resistance mechanisms driven by the tumor microenvironment(TME).Notably,various immunosuppressive cell populations—such as regulatory T cells,tumor-associated macrophages,and myeloid-derived suppressor cells—play a crucial role in fostering therapeutic resistance through multiple pathways.In addition,cancer-associated fibroblasts and the hypoxic conditions characteristic of tumor regions further diminish the effectiveness of immunotherapy.This review offers a comprehensive examination of the latest strategies to modulate the TME and overcome immune resistance.The discussion spans targeted approaches against immunosuppressive cells,metabolic regulation,phototherapy,modulation of tumor immunogenetics,as well as combination therapies and nanoparticle-mediated treatment strategies.Collectively,these developments provide novel theoretical insights and practical avenues for enhancing the overall efficacy of immunotherapeutic interventions in breast cancer.关键词
乳腺癌/肿瘤微环境/免疫治疗耐药性/免疫抑制细胞/代谢调节/联合疗法Key words
Breast cancer/Tumor microenvironment/Immunotherapy resistance/Immune-suppressive cells/Metabolic regulation/Combination therapies引用本文复制引用
刘卫丽,刘良权,王彩如,陈杰..调控肿瘤微环境以克服乳腺癌免疫治疗的耐药[J].中国肿瘤外科杂志,2026,18(1):96-104,9.基金项目
四川省科技厅-重点研发项目(2023YFS0132) （2023YFS0132）
