中国中药杂志2026，Vol.51Issue(4)：917-925,9.DOI:10.19540/j.cnki.cjcmm.20251113.709
基于巨噬细胞极化探讨糖尿病周围神经病变的作用机制与中医药防治研究进展
Research progress on mechanism of diabetes peripheral neuropathy based on macrophage polarization and prevention and treatment of traditional Chinese medicine
摘要
Abstract
Diabetic peripheral neuropathy(DPN)is one of the most common chronic complications of diabetes,characterized by a complex pathogenesis and limited clinical treatment options.In recent years,increasing attention has been drawn to the role of macrophage polarization in DPN development and progress.This paper systematically reviewed the mechanisms of M1/M2 macrophage polarization in DPN,as well as research advances in traditional Chinese medicine(TCM)for DPN prevention and treatment by macrophage polarization regulation.Under normal conditions,M1/M2 macrophages are in a dynamic balance,maintaining peripheral nerve homeostasis.In a diabetic environment,metabolic disorders,such as persistent hyperglycemia,can lead macrophages towards excessive M1 polarization,triggering pro-inflammatory factor release,neuroinflammation,and oxidative stress,ultimately causing nerve fiber damage and abnormal pain signaling.Meanwhile,a reduced quantity or impaired function of M2 macrophages weakens nerve repair and anti-inflammatory capacity.TCM can modulate macrophage polarization by multiple components at various targets.For example,active ingredients such as astragaloside Ⅳ and curcumin promote M2 polarization while inhibiting M1 polarization.Compound prescriptions like Taohong Siwu Decoction and Huangqi Guizhi Wuwu Decoction improve nerve conduction velocity by regulating signaling pathways,including nuclear transcription factor-κB(NF-κB)and Janus kinase-activator of signal transduction and transcription(JAK-STAT).This paper also analyzed current research limitations and proposed future directions,aiming to provide new insights and theoretical foundations for TCM-based DPN prevention and treatment.关键词
糖尿病周围神经病变/巨噬细胞极化/神经炎症/信号通路/中医药Key words
diabetic peripheral neuropathy/macrophage polarization/neuroinflammation/signaling pathways/traditional Chinese medicine引用本文复制引用
樊俐慧,卫向龙..基于巨噬细胞极化探讨糖尿病周围神经病变的作用机制与中医药防治研究进展[J].中国中药杂志,2026,51(4):917-925,9.基金项目
国家重点研发计划项目(2020YFE0201800) （2020YFE0201800）
河南省国家中医药传承创新中心科研专项(2023ZXZX1174) （2023ZXZX1174）
河南省中医药重点学科建设项目(豫卫中医药科教[2024]1号) （豫卫中医药科教[2024]1号）
