中国中药杂志2026，Vol.51Issue(4)：926-935,10.DOI:10.19540/j.cnki.cjcmm.20251105.301
中药多糖的结构修饰及其在递送系统中的应用
Structural modification of polysaccharides from TCM and their application in delivery systems
摘要
Abstract
The biological activity of polysaccharides from TCM is closely related to their structure.Through structural modifications,such as grafting modification and crosslinking reactions,their physicochemical properties can be significantly improved.Modified polysaccharides from TCM can form nanocarriers through self-assembly,constructing intelligent drug delivery systems and self-healing hydrogels.By esterification,etherification to graft hydrophobic small molecules,radical graft copolymerization,sulfonation reaction to graft ionic polymers,etc.,the hydrophilic-hydrophobic balance of polysaccharides can be adjusted,improving their drug loading efficiency and targeted delivery ability.By synergizing crosslinking reactions such as Schiff base reaction,ionic crosslinking,and covalent crosslinking,hydrogels with excellent properties can be constructed.After structural modification,polysaccharides from TCM can achieve efficient encapsulation of hydrophobic active ingredients,construct intelligent drug delivery systems,develop self-healing hydrogels,and build tissue scaffolds.Although they have advantages such as high plasticity and good biocompatibility as delivery systems,there are also potential issues such as stability,immune response,and quality control that need further research and resolution.关键词
中药多糖/结构修饰/药物递送系统Key words
polysaccharide from TCM/structural modification/drug delivery system引用本文复制引用
曾颖,朱卫丰,段金苓,关志宇,张紫霞,陈欣瑶,李哲,刘婧,吴文婷,岳鹏飞..中药多糖的结构修饰及其在递送系统中的应用[J].中国中药杂志,2026,51(4):926-935,10.基金项目
国家重点研发计划中医药现代化研究重点专项(2017YFC1702904) （2017YFC1702904）
国家自然科学基金项目(82474087) （82474087）
江西省人事厅博士后科研项目(252591) （252591）
江西省研究生创新专项(YC2022-s849,YC2025-s723) （YC2022-s849,YC2025-s723）
江西中医药大学校级科技创新团队发展计划项目(CXTD-22004) （CXTD-22004）
江西中医药大学中药学一流学科科研项目(JXSYLXK-ZHYAO049) （JXSYLXK-ZHYAO049）
江西中医药大学省级创新创业训练计划项目(S202510412021) （S202510412021）
江西中医药大学校级创新创业训练计划项目(202410412175) （202410412175）
